Trial reportEnvironment international2025
An exposomics analysis of 125 biomarkers of exposure to food contaminants and biomarkers of oxidative stress: a randomized cross-over chrononutrition trial of healthy adults.
Trial report in Environment international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Article
- SPE-UHPLC-MS/MS Method for Simultaneous Quantification of 50 Pesticide Biomarkers Across Nine Current-Use Chemical Classes in Human Urine.Journal of xenobiotics · 2026Article
- Risk Assessment of Chemical Mixtures in Foods: A Comprehensive Methodological and Regulatory Review.Foods (Basel, Switzerland) · 2026Review
- A Streamlined Automated Liquid Handling and 96-Well Solid-Phase Extraction for Single Low-Volume Urine Aliquot Multiclass Biomarker Analysis in Human Biomonitoring.Environmental chemistry and ecotoxicology · 2026Article
- Multiclass Assays for Measuring Environmental Chemical Mixture Exposure: Analytical Methodologies and Applications in Exposomics Research.Metabolites · 2025Review
- Scientific and Regulatory Perspectives on Chemical Risk Assessment of Pesticides in the European Union.Journal of xenobiotics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundContaminants in food counteract the beneficial effects of nutrients by interfering with their absorption/distribution/metabolism/excretion characteristics and implicated in chronic disease pathogenesis. The CIRCA CHEM chrononutrition trial was used to expand and replicate its earlier results from two biomarkers of exposure to pesticides to 125 biomarkers of exposure to food contaminants/xenobiotics, using exposomics.
objectivesWe determined i) the effect of time restricted eating (TRE) consumption of fruits and vegetables either in light or dark phases of the 24-h period (five-a-day portions for 14 days), within ad libitum diet on 125 biomarkers of exposure to food-associated contaminants in healthy adults, ii) the chrono-metabolism patterns in biomarker concentrations across/within treatment phases (light vs dark); and iii) the contaminants associated with oxidative stress, including 4-hydroxy-2-nonenal mercapturic acid (HNEMA) and 8-iso prostaglandin F2α (F2A8IP).
methodsWe characterized the temporal patterns of the TRE treatment effectiveness on biomarkers of exposure using an exposome-wide association study (ExWAS) approach, by applying linear mixed-effects models (LME) to evaluate treatment phase effects and interactions of treatment x time. Associations between contaminants and oxidative stress were further explored using LASSO regression, followed by additional LME, while adjusting for sociodemographics, body mass index and cortisol.
resultsA wide within-subject concentration variability for most biomarkers of exposure to food contaminants/xenobiotics was observed. The ExWAS approach confirmed that TRE significantly influenced the concentration and temporal patterns of multiple food contaminants/xenobiotics, including pesticides, smoking, volatile organics, phytoestrogens, parabens, and flame retardants, demonstrating their chrono-differentiated metabolism, depending on the timing of fruit and vegetable consumption within the 24-h period. Some of them (pesticides and VOCs) exhibited significant associations with lipid oxidative stress. DISCUSSION: Understanding how the circadian rhythm interacts with metabolic systems to influence the metabolism of both nutrients/bioactives and food contaminants would be of high importance in the era of precision health and precision nutrition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.