Evidence map›Paper›PMID 40749670›Full record

ArticleCancer cell2025

Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures.

Shankha Satpathy, Natalie M Clark, Yi-Ju Chen, Noshad Hosseini, Ya-Hsuan Chang, Yi Hsiao, Jonathan T Lei, Francesca Petralia, Jin-Shing Chen, Yifat Geffen and 86 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

96 authors.

Shankha SatpathyBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: shankha@broadinstitute.org.
Natalie M ClarkBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Yi-Ju ChenAcademia Sinica, Taipei, TW, Taiwan.
Noshad HosseiniUniversity of Michigan, Ann Arbor, MI 48109, USA.
Ya-Hsuan ChangNational Health Research Institutes, Miaoli County, TW, Taiwan.
Yi HsiaoUniversity of Michigan, Ann Arbor, MI 48109, USA.
Jonathan T LeiBaylor College of Medicine, Houston, TX 77030, USA.
Francesca PetraliaIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Jin-Shing ChenNational Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TW, Taiwan.
Yifat GeffenBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Massachusetts General Hospital, Boston, MA 02114, USA.
David I HeimanBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Indranil PaulBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Hanbyul ChoUniversity of Michigan, Ann Arbor, MI 48109, USA.
Michelle HollenbergNYU Grossman School of Medicine, New York, NY 10016, USA.
Giacomo B MarinoIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kuen-Tyng LinAcademia Sinica, Taipei, TW, Taiwan.
Rahul MannanUniversity of Michigan, Ann Arbor, MI 48109, USA.
C Jackson WhiteBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Joe AllenBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Shayan C AvanessianBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
M Harry KaneBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Ashley WolfeUniversity of Michigan, Ann Arbor, MI 48109, USA.
Miloni KinarivalaUniversity of Michigan, Ann Arbor, MI 48109, USA.
Wenke LiuNYU Grossman School of Medicine, New York, NY 10016, USA.
Shankara AnandBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Mong-Wei LinNational Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TW, Taiwan.
Moe HainesBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Erik J BergstromBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Grant HusseyNYU Grossman School of Medicine, New York, NY 10016, USA.
Ginny Xiaohe LiUniversity of Michigan, Ann Arbor, MI 48109, USA.
Deepak C ManiBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Hao FangAcademia Sinica, Taipei, TW, Taiwan.
Eric J JaehnigBaylor College of Medicine, Houston, TX 77030, USA.
Hasmik KeshishianBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Brecca MillerNYU Grossman School of Medicine, New York, NY 10016, USA.
Kang-Yi SuNational Taiwan University, Taipei, TW, Taiwan.
Yi-Jing HsiaoAcademia Sinica, Taipei, TW, Taiwan.
Hsao-Hsun HsuNational Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TW, Taiwan.
Min-Shu HsiehNational Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TW, Taiwan.
Kuo-Hsuan HsuTaichung Veterans General Hospital, Taichung, TW, Taiwan.
Alexi MonovoukasBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Simone GohsmanBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
John R ThorupBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Yamei DengUniversity of Michigan, Ann Arbor, MI 48109, USA.
Yo AkiyamaBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Eden DengIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Eric Sheng-Wen ChenAcademia Sinica, Taipei, TW, Taiwan.
Azra KrekIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Rodrigo EspinozaAcademia Sinica, Taipei, TW, Taiwan.
Weiping MaIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Daniel CharytonowiczIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Robert SebraIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Jyun-Hong LinAcademia Sinica, Taipei, TW, Taiwan.
Yan-Si ChenAcademia Sinica, Taipei, TW, Taiwan.
Yin-Chen HsuNational Taiwan University, Taipei, TW, Taiwan.
Ze-Shiang LinAcademia Sinica, Taipei, TW, Taiwan.
Kun-Chieh ChenChung Shan Medical University Hospital, Taichung, TW, Taiwan.
Chang-Wei YehNational Center for High-performance Computing, National Applied Research Laboratories, Hsinchu, TW, Taiwan.
Yu-Tai WangNational Center for High-performance Computing, National Applied Research Laboratories, Hsinchu, TW, Taiwan.
Alexander J LazarThe University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Mehdi MesriOffice of Cancer Clinical Proteomics Research, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD 20850, USA.
Eunkyung AnOffice of Cancer Clinical Proteomics Research, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD 20850, USA.
Xu ZhangOffice of Cancer Clinical Proteomics Research, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD 20850, USA.
Karl R ClauserBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
David FenyöNYU Grossman School of Medicine, New York, NY 10016, USA.
Arul M ChinnaiyanUniversity of Michigan, Ann Arbor, MI 48109, USA.
Bing ZhangBaylor College of Medicine, Houston, TX 77030, USA.
Li DingWashington University in St. Louis, St. Louis, MO 63110, USA.
Kelly RugglesNYU Grossman School of Medicine, New York, NY 10016, USA.
Chelsea NewtonVan Andel Research Institute, Grand Rapids, MI 49503, USA.
Hui ZhangJohns Hopkins University, Baltimore, MD 21231, USA.
Pei WangIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Galen HostetterVan Andel Research Institute, Grand Rapids, MI 49503, USA.
Gilbert S OmennUniversity of Michigan, Ann Arbor, MI 48109, USA.
Chandan Kumar-SinhaUniversity of Michigan, Ann Arbor, MI 48109, USA.
Mathangi ThiagarajanLeidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Ramaswamy GovindanWashington University in St. Louis, St. Louis, MO 63110, USA.
Paul PaikMemorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA.
Abhijit ParoliaUniversity of Michigan, Ann Arbor, MI 48109, USA.
Qing K LiJohns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
Avi Ma'ayanIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Gad A GetzBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Massachusetts General Hospital, Boston, MA 02114, USA.
Saravana M DhanasekaranUniversity of Michigan, Ann Arbor, MI 48109, USA.
Ana I RoblesOffice of Cancer Clinical Proteomics Research, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD 20850, USA.
Gee-Chen ChangChung Shan Medical University Hospital, Taichung, TW, Taiwan.
Pan-Chyr YangNational Taiwan University, Taipei, TW, Taiwan.
Sung-Liang YuNational Taiwan University, Taipei, TW, Taiwan. Electronic address: slyu@ntu.edu.tw.
Hsuan-Yu ChenAcademia Sinica, Taipei, TW, Taiwan; National Chung Hsing University, Taichung, TW, Taiwan. Electronic address: hychen@stat.sinica.edu.tw.
Alexey I NesvizhskiiUniversity of Michigan, Ann Arbor, MI 48109, USA.
Steven A CarrBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
D R ManiBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: manidr@broadinstitute.org.
Marcin P CieslikUniversity of Michigan, Ann Arbor, MI 48109, USA. Electronic address: mcieslik@med.umich.edu.
Yu-Ju ChenAcademia Sinica, Taipei, TW, Taiwan; National Taiwan University, Taipei, TW, Taiwan. Electronic address: yujuchen@gate.sinica.edu.tw.
Michael A GilletteBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: gillette@broadinstitute.org.
Taiwan Cancer Moonshot Program
Clinical Proteomic Tumor Analysis Consortium

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Michael Jason de la Cruz · 1985 to 2026
$347.4M
THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ramon E Parsons · 2015 to 2026
$35.4M
Center for Advanced Multi-Omic Characterization of CancerU24CA271012 · NCI · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI Tao Liu · 2022 to 2026
$6.6M
Proteogenomic Characterization of Tumor Tissues and Preclinical Models with High PrecisionU24CA271079 · NCI · JOHNS HOPKINS UNIVERSITY · PI DANIEL Wanyui CHAN, Hui Zhang · 2022 to 2026
$6.6M
Center of Excellence for High Throughput Proteogenomic CharacterizationU24CA210986 · NCI · BROAD INSTITUTE, INC. · PI CARR, STEVEN A, GILLETTE, MICHAEL A · 2016 to 2020
$6.4M
Proteogenomic characterization of early and late resistance mechanisms in acute myeloid leukemiaU01CA271412 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI BRIAN J DRUKER, Paul D Piehowski · 2022 to 2026
$5.8M
Proteogenomic studies to understand mechanisms and drivers of resistance to immunotherapiesU01CA271407 · NCI · FRED HUTCHINSON CANCER CENTER · PI Diwakar Davar, AMANDA G PAULOVICH · 2022 to 2026
$5.6M
Center of Excellence for High Throughput Proteogenomic CharacterizationU24CA270823 · NCI · BROAD INSTITUTE, INC. · PI STEVEN A CARR, MICHAEL A GILLETTE · 2022 to 2026
$5.3M
Mayo Clinic Center for Clinical ProteomicsU01CA271410 · NCI · MAYO CLINIC ROCHESTER · PI Rafael Fonseca, AKHILESH PANDEY · 2022 to 2026
$5.3M
Proteogenomic translator for cancer biomarker discovery towards precision medicineU24CA271114 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Avi Ma'ayan, Pei Wang · 2022 to 2026
$5.0M
Proteogenomic Predictors of Recurrence in Non-small Cell Lung CancerU01CA271402 · NCI · WASHINGTON UNIVERSITY · PI STEVEN A CARR, MICHAEL A GILLETTE · 2022 to 2026
$5.0M
Translating Pediatric Cancer Proteogenomic Data into Biological and Clinical InsightsU24CA271076 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Bing Zhang · 2022 to 2026
$5.0M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA196521NCI NIH HHS U01 CA271402NCI NIH HHS U01 CA271407NCI NIH HHS U01 CA271410NCI NIH HHS U01 CA271412NCI NIH HHS U24 CA210972NCI NIH HHS U24 CA210979NCI NIH HHS U24 CA210986NCI NIH HHS U24 CA270823NCI NIH HHS U24 CA271012NCI NIH HHS U24 CA271037NCI NIH HHS U24 CA271075NCI NIH HHS U24 CA271076NCI NIH HHS U24 CA271079NCI NIH HHS U24 CA271114
6 · The paper itself

Abstract

Lung adenocarcinomas (LUAD) are a pressing global health problem with enduring lethality and rapidly shifting epidemiology. Proteogenomic studies integrating proteomics and post-translational modifications with genomics can identify clinical strata and oncogenic mechanisms, but have been underpowered to examine effects of ethnicity, smoking and environmental exposures, or sex on this heterogeneous disease. This comprehensive proteogenomic analysis of LUAD tumors and matched normal adjacent tissues from 406 patients across diverse geographic and demographic backgrounds explores the impact of understudied driver mutations, prognostic role of chromosomal instability, patterns of immune signaling, differential and sex-specific effects of endogenous mutagens and environmental carcinogens, and pathobiology of early-stage tumors with "late-like" characteristics. Candidate protein biomarkers are proposed for unstable tumors with highly fragmented genomes and for carcinogen exposures, and a LUAD subtype-specific atlas of therapeutic vulnerabilities is presented. These observations and the associated data resource advance the objective of precision management strategies for this devastating disease.

Indexed as

AdenocarcinomaAdenocarcinoma of LungLung NeoplasmsAgedBiomarkers, TumorChromosomal InstabilityEnvironmental ExposureEthnicityFemaleHumansMaleMiddle AgedMutationPrognosisProteogenomicsBiomarkers, TumorbiomarkersCPTACgenomicsICPClung adenocarcinomamass spectrometrynever-smokersproteogenomicsPTMssmokers

Identifiers

PMID40749670
PMCPMC12393171

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.