Evidence map›Paper›PMID 40749682›Full record

ArticleCell reports. Medicine2025

Identification of immune signatures associated with both SARS-CoV-2 infection and lung transplantation.

Andrew D Hoffmann, Hannah Faisal Almubarak, Radhika Iyer, Sam E Weinberg, Joshua R Squires, Chengsheng Mao, Juncheng Wei, Shuvam Chaudhuri, Lamiaa El-Shennawy, Nurmaa K Dashzeveg and 8 more

Abstract read
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Andrew D HoffmannDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Hannah Faisal AlmubarakDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Radhika IyerDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Sam E WeinbergDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Joshua R SquiresDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Chengsheng MaoDivision of Health and Biomedical Informatics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Juncheng WeiDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Temple University, Philadelphia, PA 19140, USA.
Shuvam ChaudhuriDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Lamiaa El-ShennawyDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Nurmaa K DashzevegDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Yuzhi JiaDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Alexis R DemonbreunDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Matthew J SchipmaNUseq Core Facility, Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Yuan LuoDivision of Health and Biomedical Informatics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Suchitra SwaminathanDivision of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Division of Infectious Disease, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Michael G IsonRockville, MD 20892, USA. Electronic address: mgison@gmail.com.
Huiping LiuDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Chan Zuckerberg Biohub Chicago, Chicago, IL 60642, USA. Electronic address: huiping.liu@northwestern.edu.
Deyu FangDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: fangd@northwestern.edu.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Novel Role of Hepatic SEL1L-HRD1 ERAD in FGF21 Gene TranscriptionR01DK120330 · NIDDK · UNIVERSITY OF VIRGINIA · PI Deyu Fang, Ling Qi · 2018 to 2026
$4.9M
Clinical analysis and therapeutic development of exosomal ACE2R01AI167272 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Deyu Fang, Huiping Liu · 2022 to 2026
$3.6M
Regulation of Rhythmic m6A RNA Modification by ER‐associated DegradationR01DK126908 · NIDDK · WAYNE STATE UNIVERSITY · PI FANG, DEYU, ZHANG, KEZHONG · 2021 to 2024
$2.2M
Molecular mechanisms underlying circulating tumor cell aggregationR01CA245699 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LIU, HUIPING · 2020 to 2024
$2.0M
Develop a novel therapy with immuno- and onco-targeting dual efficacies to treat the triple negative breast cancerR01CA288387 · NCI · NORTHWESTERN UNIVERSITY · PI Deyu Fang, Huiping Liu · 2025 to 2026
$1.3M
Novel functions of PlexinB2 in circulating tumor cell clustersR01CA298232 · NCI · NORTHWESTERN UNIVERSITY · PI Huiping Liu · 2025 to 2026
$1.1M
5-laser 30-parameter FACSymphony-S6 SORP Cell Sorter from BD BiosciencesS10OD026814 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PERLMAN, HARRIS R · 2019 to 2019
$904k
FACSAria SORP Cell SorterS10OD011996 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOOLSBY, CHARLES L. · 2012 to 2012
$482k
NCI NIH HHS P30 CA060553NCI NIH HHS R01 CA245699NCI NIH HHS R01 CA288387NCI NIH HHS R01 CA298232NIAID NIH HHS R01 AI167272NIDDK NIH HHS R01 DK120330NIDDK NIH HHS R01 DK126908NIH HHS S10 OD011996NIH HHS S10 OD026814
6 · The paper itself

Abstract

Lung transplantation (lung-tx) offers the last life-saving option for patients with COVID-19-associated lung injury (CALI). We show that the RBD-specific antibodies are dramatically reduced in these CALI lung-tx patients despite a comparable frequency of CD19

Indexed as

COVID-19Lung TransplantationSARS-CoV-2AdultAgedAntibodies, ViralB-LymphocytesCytokinesFemaleHumansMaleMiddle AgedAntibodies, ViralCytokinesCALICOVID-19immunologylung transplant

Identifiers

PMID40749682
PMCPMC12432355

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.