Observational studyRMD open2025
The equivocal opposite effects of lower and higher body mass index at diagnosis on radiographic joint damage progression in early rheumatoid arthritis: an inception cohort study over 15 years.
Observational study in RMD open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Long-term Comparative Adherence and Switch Rates in Patients Receiving Advanced Therapies for Rheumatoid Arthritis After Use of One TNF Inhibitor.Rheumatology and therapy · 2026Article
- Radiographic outcome over 15 years in patients with early rheumatoid arthritis - a BARFOT-study.BMC rheumatology · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effect of Body Mass Index (BMI) on long-term radiographic damage in an inception rheumatoid arthritis (RA) cohort.
methodsThe study population, n=1813, originated from the observational Better AntiRheumatic FarmacoTherapy cohort. X-rays of hands and feet at inclusion, 1, 2, 5, 8 and 15 years were quantified for erosion score (ES), joint space narrowing (JSN) and the sum of modified Sharp-van der Heijde total score (mTSS). Patients were grouped by baseline BMI categories, including additional cut-off BMI ≥27 kg/m
resultsInverse relationship between BMI and log-transformed mTSS was identified. In general, patients with higher BMI, compared with normal weight and/or underweight patients, had more favourable radiographic outcomes defined by annualised progression rates of mTSS, ES and JSN, less frequent rapid and clinically relevant radiographic progression, and maintained structural integrity. In contrast to consistently higher 28-joint Disease Activity Score (DAS28) levels, BMI ≥30 kg/m
conclusionsBMI is one of the determinants of radiographic progression in early RA. Lower and higher BMI have opposite effects on radiographic progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.