Evidence map›Paper›PMID 40751104›Full record

ArticleJournal of neurology2025

Diagnostic performance of choroid plexus and cerebrospinal fluid space volumes in idiopathic normal pressure hydrocephalus.

Ziang Deng, Zhouyang Huang, Honglin Ge, Haoxiang Wang, Yuanyou Li, Keru Huang, Na Hu, Liangxue Zhou

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ziang Deng *Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Zhouyang Huang *Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Honglin GeDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Haoxiang WangDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Yuanyou LiDepartment of Pediatric Neurosurgery, West China Second University Hospital, Sichuan University, Chengdu, China.
Keru HuangDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Na Hu *Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
Liangxue Zhou *Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China. Zhlxlll@163.com.ORCID http://orcid.org/0000-0001-9991-6358

Funding

National Natural Science Foundation of China 82473334
6 · The paper itself

Abstract

backgroundChoroid plexus (CP) enlargement is found in Alzheimer's disease (AD), multiple sclerosis, and Parkinson's disease. As a source of cerebrospinal fluid (CSF), the diagnostic value of CP enlargement in idiopathic normal pressure hydrocephalus (iNPH) is unknown. PURPOSE: This study aimed to evaluate the diagnostic performance of CP and CSF space volumes in iNPH.

methodsWe retrospectively collected patients with iNPH admitted to West china Hospital of Sichuan University (Chengdu, China) between June 2016 and December 2022 and patients with AD and healthy controls (HCs) from the ADNI database. CP and CSF space volumes were evaluated on magnetization prepared rapid gradient-echo (MPRAGE) MRI. We compared them among iNPH, AD, and HC group, and caluculated the area under receiver operating characteristic curves (AUC).

resultsA total of 32 patients with iNPH (mean age: 75 ± 5.7; 23 males), 32 patients with AD (mean age: 75 ± 4.3; 23 males), and 32 HCs (mean age: 75 ± 2.4; 23 males) were included. The CP volume in the iNPH group (1769 ± 486 mm

conclusionsCP volume showed good performance in distinguishing iNPH from non-iNPH patients (AD and HC). CP volume may be a good imaging indicator in the diagnosis of iNPH.

Indexed as

Alzheimer DiseaseChoroid PlexusHydrocephalus, Normal PressureAgedAged, 80 and overFemaleHumansMagnetic Resonance ImagingMaleRetrospective StudiesChoroid plexusDiagnosisIdiopathic normal pressure hydrocephalus

Identifiers

PMID40751104

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.