ArticleBMC psychiatry2025
Association between long-term visit-to-visit resting heart rate variability and cognitive decline: evidence from two national cohorts.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Trajectories of cognitive decline before and after new-onset dual sensory impairment: findings from two longitudinal studies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive impairment is a major public health problem. This study aimed to examine the association between long-term visit-to-visit resting heart rate variability (RHRV) and cognitive dysfunction among the general population.
methodsData was derived from the Health and Retirement Study (HRS) and the China Health and Retirement Longitudinal Study (CHARLS). Variation independent of mean (VIM) was used to assess participants’ RHRV in the main analyses. Cognitive functions in both cohorts were measured by using tests including memory, attention, and orientation, and a standardized Z score was calculated. Linear mixed models and restricted cubic splines were adopted to explore the association between RHRV and cognitive decline.
resultsThere were 7,582 and 4,085 eligible participants from the HRS and the CHARLS in the analyses, respectively. After adjusting for covariates, VIM of RHRV was significantly associated with global cognitive function (HRS: β for per-SD increment = − 0.022 [95% CI, − 0.040 to − 0.005]; CHARLS: β for per-SD increment = -0.023 [95% CI, − 0.045 to − 0.000]). Similar results were observed from several sensitivity analyses, including using average real variability and coefficient of variation for RHRV, additionally adjusted for physical activity, excluding participants who had heart problems at baseline, and further adjusting for the C-reactive protein in the CHARLS.
conclusionOur results suggest that RHRV was independently associated with cognitive function in the general population.
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