Evidence map›Paper›PMID 40751869›Full record

Observational studyHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2025

Three months of bempedoic acid treatment does not affect cystatin C-based estimation of glomerular filtration rate.

Leandra Serio, Antonella Paolucci, Maria Ester Carugno, Sofia Cappannari, Alessia Cecchini, Marianna Litterio, Rita Del Pinto, Claudio Ferri

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Leandra SerioUnit of Internal Medicine and Nephrology, Department of Life, Environmental Science and Health, Center for Hypertension and Cardiovascular Prevention, School of Internal Medicine, University of L'Aquila, San Salvatore Hospital, Rita Levi Montalcini Building Delta 6, 67100, Coppito, L'Aquila, AQ, Italy.
Antonella PaolucciUnit of Internal Medicine and Nephrology, Department of Life, Environmental Science and Health, Center for Hypertension and Cardiovascular Prevention, School of Internal Medicine, University of L'Aquila, San Salvatore Hospital, Rita Levi Montalcini Building Delta 6, 67100, Coppito, L'Aquila, AQ, Italy.
Maria Ester CarugnoUnit of Internal Medicine and Nephrology, Department of Life, Environmental Science and Health, Center for Hypertension and Cardiovascular Prevention, School of Internal Medicine, University of L'Aquila, San Salvatore Hospital, Rita Levi Montalcini Building Delta 6, 67100, Coppito, L'Aquila, AQ, Italy.
Sofia CappannariUnit of Internal Medicine and Nephrology, Department of Life, Environmental Science and Health, Center for Hypertension and Cardiovascular Prevention, School of Internal Medicine, University of L'Aquila, San Salvatore Hospital, Rita Levi Montalcini Building Delta 6, 67100, Coppito, L'Aquila, AQ, Italy.
Alessia CecchiniUnit of Internal Medicine and Nephrology, Department of Life, Environmental Science and Health, Center for Hypertension and Cardiovascular Prevention, School of Internal Medicine, University of L'Aquila, San Salvatore Hospital, Rita Levi Montalcini Building Delta 6, 67100, Coppito, L'Aquila, AQ, Italy.
Marianna LitterioUnit of Internal Medicine and Nephrology, Department of Life, Environmental Science and Health, Center for Hypertension and Cardiovascular Prevention, School of Internal Medicine, University of L'Aquila, San Salvatore Hospital, Rita Levi Montalcini Building Delta 6, 67100, Coppito, L'Aquila, AQ, Italy.
Rita Del PintoUnit of Internal Medicine and Nephrology, Department of Life, Environmental Science and Health, Center for Hypertension and Cardiovascular Prevention, School of Internal Medicine, University of L'Aquila, San Salvatore Hospital, Rita Levi Montalcini Building Delta 6, 67100, Coppito, L'Aquila, AQ, Italy. rita.delpinto@univaq.it.ORCID http://orcid.org/0000-0003-4058-0655
Claudio FerriUnit of Internal Medicine and Nephrology, Department of Life, Environmental Science and Health, Center for Hypertension and Cardiovascular Prevention, School of Internal Medicine, University of L'Aquila, San Salvatore Hospital, Rita Levi Montalcini Building Delta 6, 67100, Coppito, L'Aquila, AQ, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionBempedoic acid can interfere with creatinine excretion, thereby potentially altering the calculation of glomerular filtration rate (eGFR), but is not known to have an effect on cystatin C metabolism.

aimThe aim of this pilot observational study was to assess the impact of 3-months bempedoic acid treatment on renal function assessed by serum creatinine and cystatin C.

methodsConsecutive hypercholesterolemic outpatients with indication to be started on bempedoic acid and available serum creatinine and cystatin C levels were enrolled. Follow-up (45-90 days) renal function markers were assessed. Lipid profile, uric acid levels, and CRP levels were also recorded.

resultsBempedoic acid reduced LDL-c and total cholesterol levels by day 45. No changes were observed in HDL-c, triglycerides, Lp(a), serum creatinine, eGFR

conclusionsThree-months administration of bempedoic acid did not affect cystatin C levels. Adequately powered studies are needed to test these findings and, ultimately, the renal safety of bempedoic acid.

Indexed as

Cystatin CFatty AcidsGlomerular Filtration RateHypercholesterolemiaHypolipidemic AgentsKidneyAgedBiomarkersCreatinineDicarboxylic AcidsFemaleHumansMaleMiddle AgedPilot ProjectsPredictive Value of Tests8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acidBiomarkersCreatinineCST3 protein, humanCystatin CDicarboxylic AcidsFatty AcidsHypolipidemic AgentsBempedoic acidCreatinineCystatin CGlomerular filtration rate

Identifiers

PMID40751869
PMCPMC12474684

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.