ArticleClinical rheumatology2025
Identifying plasma proteins and immunocyte phenotypes as risk factors in rheumatoid arthritis: The role of EPHA3 and CD28
Article in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Genetically prioritized plasma proteins in intracerebral hemorrhage identified by Mendelian randomization with functional evidence of neuronal vulnerability.American journal of translational research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectivesRheumatoid arthritis (RA) is a chronic systemic autoimmune disease whose pathogenesis involves the participation of numerous plasma proteins and immune cells, but their relationships are unclear. So we set out to thoroughly examine the causal link between 4907 plasma proteins and RA and to identify the involvement of 731 immunocyte phenotypes as potential mediators.
methodsUsing publicly available genome-wide association studies (GWAS) data, 5 Mendelian randomization (MR) methods (inverse variance weighted (IVW), weighted median, MR-Egger, simple mode, weighted mode) were applied for analysis, along with sensitivity analyses.
results27 plasma proteins and 10 immunocyte phenotypes were causally linked to RA, with most of the proteins serving as drug targets. Ephrin type-A receptor 3 (EPHA3) was a significant risk factor for RA (odds ratio (OR) = 1.312, 95% confidence interval (CI) [1.102, 1.562], Beta = 0.272, p < 0.01). CD28 on CD28
conclusionPlasma proteins and immunocyte phenotypes linked to RA have been identified using MR, including EPHA3, which may elevate RA risk by influencing CD28 on CD28
Indexed as
Identifiers
40751895What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.