Evidence map›Paper›PMID 40752010›Full record

ArticleJournal of proteome research2025

Myeloid-Derived Growth Factor-Regulated Oncogenesis in Lung Adenocarcinoma Is Associated with EGFR Status and Cancer Aggressiveness.

Ting-Feng Hsiao, Chih-Liang Wang, Yi-Cheng Wu, Chia-Yu Kuo, Ke-Wei Lin, Wen-Yu Chuang, Chi-Ju Yeh, Chia-Chun Wu, Ko-Jiunn Liu, Gee-Chen Chang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of proteome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ting-Feng HsiaoGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0003-4074-9019
Chih-Liang WangSchool of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Yi-Cheng WuDepartment of Thoracic Surgery, Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan.
Chia-Yu KuoGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Ke-Wei LinGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Wen-Yu ChuangDepartment of Pathology, Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan.
Chi-Ju YehDepartment of Pathology, Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan.
Chia-Chun WuMolecular Medicine Research Center, Chang Gung University, Taoyuan 33302, Taiwan.
Ko-Jiunn LiuNational Institute of Cancer Research, National Health Research Institutes, Tainan 704016, Taiwan.
Gee-Chen ChangSchool of Medicine, and Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Kun-Yi ChienGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0002-1723-0406
Jau-Song YuGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Chia-Jung YuGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0001-6301-7190

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors have transformed lung adenocarcinoma (LUAD) treatment in EGFR-mutant (MT) patients, but strategies targeting wild-type (WT) EGFR tumors remain necessary. This study analyzed a diverse LUAD patient cohort with EGFR mutation statuses and wild-type profiles for ALK and KRAS to identify stage-specific biomarkers. Using quantitative proteomics and multiomics, we discovered 21 dysregulated proteins in early-stage EGFR-WT LUAD, identifying myeloid-derived growth factor (MYDGF) as a key candidate biomarker. Elevated MYDGF levels in tissue (

Indexed as

Adenocarcinoma of LungCarcinogenesisLung NeoplasmsAgedBiomarkers, TumorCell Line, TumorCell MovementErbB ReceptorsFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedMutationPrognosisProteomicsBiomarkers, TumorEGFR protein, humanErbB Receptorsbiomarkerlung adenocarcinomamyeloid-derived growth factorquantitative proteomicswild-type EGFR

Identifiers

PMID40752010
PMCPMC12419241

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.