ArticleEuropean journal of medical research2025
Early-onset colorectal cancer: a retrospective study of demographic, clinicopathological, and molecular characteristics in a single Chinese center.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Sex-related differences in pathological characteristics of colorectal cancer: a retrospective study.Discover oncology · 2026Article
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6 authors.
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Abstract
backgroundEarly-onset CRC is typically defined as CRC diagnosed in individuals under the age of 50 years. The global incidence and mortality rates of early-onset CRC have gradually increased. The clinicopathological features and pathogenesis of early-onset CRC have still not been fully elucidated, and related data are lacking in China. This research aimed to examine the demographic and clinicopathological characteristics of early-onset CRC patients in China. MATERIALS AND
methodsThis retrospective study included all patients newly diagnosed with CRC between 2019 and 2021 in the General Surgery Department of the Second Xiangya Hospital, Central South University.
resultsA total of 1206 CRC cases were included. Among them, 180 cases (14.9%) were early-onset CRC, and 1026 cases were late-onset CRC, all of which were collected and analyzed. Early-onset CRC patients had significantly longer median symptom durations (90 vs. 60 days, P < 0.001). Patients with late-onset CRC less commonly had a family history than patients with early-onset CRC did (25.60% vs. 17.93%, P = 0.022). There was no direct relationship between symptom duration and disease stage at presentation in early-onset CRC patients (P = 0.750). Early-onset CRC patients were more likely to present with advanced disease (stage IV) compared to late-onset CRC patients (24.44% vs. 13.45%, P < 0.001). Additionally, early-onset CRC patients were more likely to present with poorly differentiated tumors (29.81% vs. 12.70%, P < 0.001) and with mucinous or signet-ring cell histology (22.40% vs. 14.17%, P = 0.011) compared to late-onset CRC patients. Deficient mismatch repair (dMMR) tumors were more common in early-onset CRC patients (15.90% vs. 6.28%, P < 0.001). Among early-onset CRC patients, no significant differences were observed in age, sex, BMI, or tumor pathology between those with right-sided and left-sided tumors.
conclusionsEarly-onset CRC has different epidemiology, pathology, and molecular features than late-onset CRC in China. More research is needed to better understand the pathophysiology of early-onset CRC and why there are different characteristics between the two types of CRC.
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