ArticleJournal of molecular neuroscience : MN2025
ZDHHC4 Influences Obsessive-Compulsive Disorder Risk Through Imaging-Derived Phenotypes: A Mendelian Randomization Study.
Article in Journal of molecular neuroscience : MN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obsessive-compulsive disorder (OCD) affects 1-3% of the global population and ranks among the top ten most disabling medical conditions. While abnormalities in cortico-striato-thalamo-cortical circuits have been implicated in OCD pathophysiology, the molecular mechanisms underlying these neural aberrations remain incompletely understood. Protein palmitoylation, a reversible post-translational modification, is essential for neuronal development and synaptic function, potentially affecting neurotransmitter systems linked to OCD. We employed Mendelian randomization (MR) to explore causal relationships between the expression of palmitoylation-related genes, imaging-derived phenotypes (IDPs), and OCD susceptibility. Analysis of 22 palmitoylation-related genes revealed that decreased expression of the palmitoyl acyltransferase ZDHHC4 significantly increases OCD risk (OR = 0.882, 95% CI: 0.831-0.935, p = 2.73 × 10
Indexed as
Identifiers
40753321What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.