Evidence map›Paper›PMID 40753498›Full record

ArticleJournal of natural products2025

Alteration in Amino Acid Composition and Configuration in Cyanobacterial Peptides Affects Biological Activity.

Runjie Xia, Hannuo Xie, Allyson M Solorzano Mahmud, Matthew J Bertin

Abstract read
In one paragraph

Article in Journal of natural products, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Runjie XiaDepartment of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Hannuo XieDepartment of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Allyson M Solorzano MahmudSt. Vincent-St. Mary High School, Akron, Ohio 44303, United States.
Matthew J BertinDepartment of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States.ORCID 0000-0002-2200-0277

Funding

Shifting paradigms to emerging toxins in freshwater cyanobacterial bloomsR21ES033758 · NIEHS · UNIVERSITY OF RHODE ISLAND · PI BERTIN, MATTHEW JOHN · 2022 to 2023
$415k
NIEHS NIH HHS R21 ES033758
6 · The paper itself

Abstract

Cyanobacterial blooms are a significant environmental concern due to their production of toxic metabolites with potential impacts on ecosystem and human health. Microcystin-LR and microcystin congeners are a major concern with respect to human exposure and intoxication, but there are hundreds of characterized cyanobacterial peptides and metabolites that are of interest for their environmental impact in a variety of classes such as cyanopeptolins/micropeptins, microviridins, microginins, and anabaenopeptins. In this study, we report the isolation and characterization of new micropeptins (

Indexed as

Amino AcidsCyanobacteriaMicrocystinsPeptidesChymotrypsinHumansLeukocyte ElastaseMolecular StructureOligopeptidesPeptides, CyclicAmino AcidsChymotrypsinLeukocyte ElastaseMicrocystinsmicrogininOligopeptidesPeptidesPeptides, Cyclic

Identifiers

PMID40753498
PMCPMC12418302

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.