Evidence map›Paper›PMID 40754613›Full record

ArticleAnnals of biomedical engineering2025

Towards the Intravascular Delivery of 3D-printed Leached SMP for Endovascular Treatment of Intracranial Aneurysm.

Sergio Ruiz Vega, Juan C Mesa, Coral Blanquer, Cristian Barinaga, Tanner L Cabaniss, Angel Enriquez, Bradley N Bohnstedt, Chung-Hao Lee, Hyowon Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sergio Ruiz Vega *Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.ORCID http://orcid.org/0009-0003-1110-2926
Juan C Mesa *Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.ORCID http://orcid.org/0000-0002-1890-5241
Coral BlanquerWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.ORCID http://orcid.org/0009-0002-4695-3707
Cristian BarinagaWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.ORCID http://orcid.org/0009-0006-6595-8721
Tanner L CabanissSchool of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK, 73019-0390, USA.ORCID http://orcid.org/0000-0002-6423-7571
Angel EnriquezWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.ORCID http://orcid.org/0000-0001-8325-3545
Bradley N BohnstedtDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. bbohnste@iu.edu.ORCID http://orcid.org/0000-0001-6254-2313
Chung-Hao LeeBiomechanics and Biomaterials Design Laboratory (BBDL), The Bioengineering Department, University of California Riverside, Riverside, CA, 92521, USA. chunghal@ucr.edu.ORCID http://orcid.org/0000-0002-8019-3329
Hyowon LeeWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA. hwlee@purdue.edu.ORCID http://orcid.org/0000-0001-7628-1441

Funding

Improving outcomes in endovascular treatment of intracranial aneurysms: Combining additive manufacturing, in-silico modeling, and shape memory polymersR01HL159475 · NHLBI · UNIVERSITY OF OKLAHOMA · PI Chung-Hao Lee · 2022 to 2026
$3.3M
NHLBI NIH HHS R01 HL159475NHLBI NIH HHS R01HL159475
6 · The paper itself

Abstract

purposeIntracranial aneurysms (ICAs) pose a serious clinical risk due to their potential for rupture, leading to subarachnoid hemorrhage, high morbidity, and mortality. This study aims to develop a proof-of-concept device for the targeted delivery of shape memory polymers (SMPs)-based embolic devices to improve aneurysm occlusion and reduce recurrence.

methodsA novel system was designed combining a radial compression fixture and an electronic device for Joule heating and electrolytic detachment (ED). Three SMP geometries (5, 6.5 mm spherical, and patient-specific) were evaluated for the shape recovery and thermal responses. In-vitro testing was performed using 6.5 mm and patient-specific geometries in PDMS aneurysm phantoms under physiological relevant conditions utilizing ovine blood.

resultsControlled activation of the SMPs at currents of 400 mA achieved reproducible shape recovery ratios (SRRs) up to 75.71%, with detachment occurring at < 100 mA. Surface temperatures remained below 45 °C. In-vitro deployment resulted in aneurysm sac occlusion of 90.32% (patient-specific) and 94.12% (idealized), without evidence of thermal damage or gas accumulation. Flow visualization confirmed reduced bubble entry into the aneurysm sac post-deployment.

conclusionThis study demonstrates the feasibility of a targeted delivery system for patient-specific ICA treatment using SMPs. While further refinement and in-vivo validation are required, these findings highlight the potential of SMPs as durable embolization devices capable of conforming to complex aneurysm geometries and providing more effective occlusion compared to current methods.

Indexed as

Endovascular ProceduresIntracranial AneurysmPrinting, Three-DimensionalSmart MaterialsAnimalsHumansPhantoms, ImagingSheepSmart MaterialsElectrolytic detachment (ED)Intracranial aneurysm (ICAs)Intracranial embolizationJoule-heatingRadial compressionShape memory polymers (SMPs)

Identifiers

PMID40754613
PMCPMC12399225

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.