ArticleCurrent neuropharmacology2025
Analyses of Nogo-Family Genes in Mouse and Human Microglia Omics Datasets Identify
Article in Current neuropharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Altered Microglia-Neuron Crosstalk and Regional Heterogeneity in Alzheimer's Disease Revealed by Single-Nucleus RNA Sequencing.International journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Microglia are the innate immune cells of the brain. Recent single cell and nucleus sequencing along with other omics technologies are leading the way for new discoveries related to microglial function and diversity. The Nogo-signaling system is a prime target for investigation with these tools as it has previously been neglected in microglia. The Nogo-signaling system consists of approximately 20 proteins, including ligands, receptors, co-receptors, and endogenous inhibitors known for their neuronal plasticity restricting properties via RhoA and ROCK1/ROCK2 activation, and have recently been implicated in microglial function. Here, we explore expression patterns of Nogo-family genes in the mouse and human brain. In mice, we focus on brain cell type enrichment, patterns of expression in microglia from embryonic stages to adulthood, sex differences, and changes in expression in acute and chronic inflammatory contexts from publicly available RNAseq and RiboTag translational profiling datasets. We identified differential expression of Nogo-family genes across age, sex, and disease/injury in mice. To analyze human microglia, we utilize a new tool, the
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.