Evidence map›Paper›PMID 40755217›Full record

ArticleAIDS (London, England)2025

Tenofovir diphosphate concentrations in dried blood spots predict future HIV suppression but not virologic failure in adolescents with HIV.

Sampson Antwi, Hongmei Yang, Anthony Enimil, Charles Martyn-Dickens, Albert Dompreh, Eugenia Sly-Moore, Dennis Bosomtwe, Aikins Kofi Amissah, Oluwayemisi Ojewale, Priscilla Asiedu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sampson AntwiDepartment of Child Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi.
Hongmei YangDepartment of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY.
Anthony EnimilDepartment of Child Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi.
Charles Martyn-DickensDirectorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Albert DomprehDepartment of Clinical Microbiology, Komfo Anokye Teaching Hospital.
Eugenia Sly-MooreDirectorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Dennis BosomtweDirectorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Aikins Kofi AmissahDirectorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Oluwayemisi OjewaleDepartment of Medicine, University of Florida College of Medicine, Gainesville, FL.
Priscilla AsieduDirectorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Augustina Frimpong AppiahDirectorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Theresah OpokuDirectorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Ama D SarfoDirectorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Isaac Kusi-AmponsahDepartment of Clinical Microbiology, Komfo Anokye Teaching Hospital.
Lane R BushmanColorado Antiviral Pharmacology Laboratory and Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, CO.
Lucas EllisonColorado Antiviral Pharmacology Laboratory and Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, CO.
Peter L AndersonColorado Antiviral Pharmacology Laboratory and Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, CO.
Awewura KwaraDepartment of Medicine, University of Florida College of Medicine, Gainesville, FL.

Funding

Pharmacokinetics of Anti-tuberculosis and Antiretroviral Drugs in ChildrenR01HD071779 · NICHD · UNIVERSITY OF FLORIDA · PI KWARA, AWEWURA JACOB · 2012 to 2022
$6.0M
NICHD NIH HHS R01 HD071779
6 · The paper itself

Abstract

We investigated whether tenofovir diphosphate (TFV-DP) concentration in dried blood spot (DBS) predicted future virologic outcome. Of 52 adolescents with HIV, 46% had virologic suppression, and 44% had virologic failure. TFV-DP concentration in DBS was associated with virologic suppression but not virologic failure. Twenty-six percentage of participants with virologic failure had high levels of antiretroviral adherence at earlier visits. Virologic failure in the setting of high adherence may suggest the presence of HIV drug resistance.

Indexed as

AdenineAnti-HIV AgentsDried Blood Spot TestingHIV InfectionsOrganophosphatesAdolescentFemaleHumansMaleSustained Virologic ResponseTreatment FailureViral LoadAdenineAnti-HIV AgentsOrganophosphatestenofovir diphosphate

Identifiers

PMID40755217
PMCPMC12327762

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.