ArticleAlcohol, clinical & experimental research2025
Alcohol consumption in P301S mice accelerates gait impairments, modifies aggregation of pathological tau and alters microglia within the hippocampus.
Nicole M Maphis, Dominic A Furlano, Seth A David, David N Linsenbardt
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In one paragraphArticle in Alcohol, clinical & experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
4 authors.
Dominic A FurlanoDepartment of Neurosciences, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Seth A DavidDepartment of Neurosciences, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Funding
University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7MUnderstanding neurophysiological deficits in response inhibition in children with FASDP50AA022534 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Carlos Fernando Valenzuela · 2014 to 2026
$21.5MFAIR Data Competency and Machine Learning Readiness for Biomedical ScientistsK12GM088021 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI REBECCA S. HARTLEY, Diane Lidke · 2009 to 2026
$16.4MAlcohol Research Training: Methods & MechanismsT32AA018108 · NIAAA · UNIVERSITY OF NEW MEXICO · PI Katie A Witkiewitz · 2010 to 2026
$5.6MNeurophysiological Genetics of Binge DrinkingR01AA031496 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LINSENBARDT, DAVID NATHANIEL · 2025 to 2025
$2.9MRepeated Binge Drinking and the Genetic Regulation of Corticostriatal SynchronyR00AA025120 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LINSENBARDT, DAVID NATHANIEL · 2020 to 2022
$993kRepeated Binge Drinking and the Genetic Regulation of Corticostriatal SynchronyK99AA025120 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LINSENBARDT, DAVID NATHANIEL · 2017 to 2018
$316kElectrophysiological ensembles organization during alcohol cue-induced intake andF32AA022268 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LINSENBARDT, DAVID NATHANIEL · 2013 to 2015
$155kNational Institute on Alcohol Abuse and Alcoholism, New Mexico Alcohol Research Center AA022268National Institute on Alcohol Abuse and Alcoholism, New Mexico Alcohol Research Center AA025120-05S1National Institute on Alcohol Abuse and Alcoholism, New Mexico Alcohol Research Center P50-AA022534National Institute on Alcohol Abuse and Alcoholism, New Mexico Alcohol Research Center T32-CASAA (5-T32AA018108-15)NIAAA NIH HHS F32 AA022268NIAAA NIH HHS K99 AA025120NIAAA NIH HHS L70 AA030440NIAAA NIH HHS P50 AA022534NIAAA NIH HHS R00 AA025120NIAAA NIH HHS R01 AA031496NIAAA NIH HHS T32 AA018108NIGMS NIH HHS COBRE P20-GM109089NIGMS NIH HHS IRACDA (GM088021)NIGMS NIH HHS K12 GM088021NIGMS NIH HHS P20 GM109089NIH HHS LRP-REACH
6 · The paper itselfAbstract
backgroundExcessive alcohol use has emerged as the strongest modifiable risk factor for the development of Alzheimer's disease (AD), but the underlying neural mechanisms are only beginning to be understood. Recent preclinical work suggests that alcohol consumption may have an impact on many pathologies and phenomena crucial to the development and pathogenesis of AD. However, little attention has been focused on pure tauopathy models to closely examine tau pathogenesis and neuroinflammation within a voluntary alcohol exposure paradigm.
methodsWe exposed a mouse model of pathological tau (pTau), P301S, to a voluntary alcohol paradigm known as drinking-in-the-dark (DID) for 21 days of voluntary daily alcohol consumption.
resultsIn P301S mice, moderate alcohol consumption contributed to gait disruptions, acceleration of pTau spread, and enhancement of damage-associated microglia.
conclusionsThis work identifies key interactions between alcohol and AD-related phenotypes which set the stage for future investigation into the neurobiological mechanisms behind these interactions.
Indexed as
Alcohol DrinkingEthanolGaitGait Disorders, NeurologicHippocampusMicrogliatau ProteinsAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, TransgenicEthanolMapt protein, mousetau ProteinsalcoholAlzheimer's diseasegaitneuroinflammationpathological tau
Identifiers
PMID40755227
PMCPMC12934799
What Socratic holds
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