ReviewPeerJ2025
The role of mast cells in allergic rhinitis.
Review in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Research progress on the molecular mechanisms of tanshinone IIA in the treatment of cardiovascular and cerebrovascular diseases (Review).International journal of molecular medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: In recent decades, mast cells and their mediators have been increasingly recognized as central players in the pathogenesis of allergic rhinitis (AR), a complex chronic nasal disease characterized by pathological changes influenced by genetic factors, various immune cells, and environmental exposures. Mast cells are pivotal in allergic reactions, orchestrating inflammation and airway contraction through the secretion of diverse mediators. Prominent among these mediators are histamine and bioactive lipids, whose physiological effects are prominently observed during the acute phase of allergic reactions. The accumulation of mast cells in specific areas of allergic rhinitis may correlate with the disease's phenotype, progression, and severity. Rationale for this review: Despite the substantial progress in understanding the role of mast cells in allergic rhinitis, several critical gaps remain in our knowledge. The complex interplay between mast cells, their mediators, and the immune system in the context of AR is still not fully elucidated. Moreover, the specific mechanisms underlying the recruitment and activation of mast cell progenitor cells in the nasal mucosa remain poorly understood. Addressing these gaps is essential for developing more effective therapeutic strategies for allergic rhinitis. This review aims to provide a comprehensive and up-to-date synthesis of the current literature on the role and development of mast cells and their progenitor cells in allergic rhinitis, including the activation pathways implicated in the pathogenesis. Target audience: This review is intended for a broad audience, including researchers in the fields of immunology, allergy, and respiratory medicine, as well as clinicians who manage patients with allergic rhinitis. By summarizing the latest findings and highlighting the unresolved questions, this review aims to serve as a valuable reference for future research directions in mast cells and allergic rhinitis, ultimately contributing to improved patient care and outcomes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.