Evidence map›Paper›PMID 40755902›Full record

ArticleMaterials today. Bio2025

Type 1 diabetes mellitus (T1DM) does not affect whole blood responses to alginate-based microspheres despite plasma lipid and glucose differences.

Kalaiyarasi Vasuthas, Sverre Christian Christiansen, Joachim Sebastian Kjesbu, Liv Ryan, Trygve Andreassen, Geir Slupphaug, Berit L Strand, Jørgen Stenvik, Anne Mari A Rokstad

Abstract read
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In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kalaiyarasi VasuthasCenter of Molecular Inflammation Research (CEMIR), NTNU, Norway.
Sverre Christian ChristiansenDepartment of Clinical and Molecular Medicine, NTNU, Norway.
Joachim Sebastian KjesbuDepartment of Biotechnology and Food Science, NTNU, Norway.
Liv RyanCenter of Molecular Inflammation Research (CEMIR), NTNU, Norway.
Trygve AndreassenDepartment of Circulation and Medical Imaging, NTNU, Trondheim, Norway.
Geir SlupphaugDepartment of Clinical and Molecular Medicine, NTNU, Norway.
Berit L StrandDepartment of Biotechnology and Food Science, NTNU, Norway.
Jørgen StenvikCenter of Molecular Inflammation Research (CEMIR), NTNU, Norway.
Anne Mari A RokstadCenter of Molecular Inflammation Research (CEMIR), NTNU, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Encapsulation of insulin-producing cells holds significant therapeutic potential for treating type 1 diabetes (T1DM). The impact of diabetic conditions on host responses is not well understood. This study is the first to compare ex-vivo whole blood responses to alginate microbeads in T1DM subjects versus healthy controls. Nineteen T1DM and 27 healthy controls were included. Alginate microbeads varying in guluronic acid content (68 % and 47 % G), sulfated alginate/alginate ratios (10/90 and 20/80), or containing poly-L-lysine were characterised regarding activation of coagulation, complement, and inflammatory cytokine release in whole blood. Responses to heat-killed microbes (

Indexed as

Alginate microspheresImmune responseLipoproteinsSulfated alginateT1DMWhole blood model

Identifiers

PMID40755902
PMCPMC12318296

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.