ArticleNanotechnology, science and applications2025
Evaluation of the Effect of Formulation Composition and Physicochemical Properties of Omeprazole and Bisoprolol Hemifumarate on Electrospun Nanofibers Characteristics.
Article in Nanotechnology, science and applications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Development of Prolonged-Release Orodispersible Minitablets Containing Bisoprolol Fumarate.Pharmaceutics · 2026Article
- The Impact of the Core-Shell Fiber Composition on the Properties and Stability of the Electrospun Films.Nanotechnology, science and applications · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Electrospinning enables the formation of nanofibers by elongating a polymer solution droplet in a high-voltage electrostatic field. The drug substance incorporated into nanofibrous matrix exhibits unique dissolution characteristics, modifiable by polymers selection. The physicochemical properties of the drug substance may also influence structural and functional attributes of the nanofibers. This study aimed to produce nanofibers loaded with small-molecule drugs - omeprazole (OMZ) and bisoprolol hemifumarate (BIS) to investigate how drug and polymer properties influence fiber formation and drug release. The effect of compression into minitablets on dissolution parameters was also assessed. Methods: Ethanolic solutions of Eudragit Results: Nanofibers morphology depended on the API and polymers composition. The BIS fibers were nanosized, while OMZ fibers showed heterogeneous thicknesses ranging from 0.54 µm to 5.7 µm. The drug substances were amorphous in nanofibers. OMZ formulations exhibited a sustained release except OMZ_PVP fibers, which released OMZ immediately. The BIS-loaded nanofibers demonstrated a rapid and nearly complete drug release, except for the BIS_ERL+ERS_7+3 formulation, which exhibited prolonged release. Compression of fibers into minitablets preserved the sustained drug release for both drug substances. Conclusion: The study proves that nanofibers based on Eudragit RL/RS and PVP can be obtained by the electrospinning method. BIS properties such as good solubility, balanced hydrophobic-lipophilic nature, surface charge, and amorphous form contributed to its rapid release, unlike OMZ.
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