Evidence map›Paper›PMID 40756183›Full record

ArticleResearch and practice in thrombosis and haemostasis2025

Genome-wide association and linkage analysis of histidine-rich glycoprotein identifies common variants associated with plasma histidine-rich glycoprotein concentrations.

Mary I Underwood, Ayse Bilge Ozel, Tanay Deepak, Beth McGee, Dave Siemieniak, Rida A Malik, Cherie Teney, Colin A Kretz, Jeffery Weitz, Karl C Desch

Abstract read
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In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mary I UnderwoodDepartment of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
Ayse Bilge OzelDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Tanay DeepakCollege of Literature, Science, and the Arts, University of Michigan, Ann Arbor, Michigan, USA.
Beth McGeeLife Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.
Dave SiemieniakLife Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.
Rida A MalikThrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.
Cherie TeneyThrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.
Colin A KretzThrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.
Jeffery WeitzThrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.
Karl C DeschDepartment of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.

Funding

The Molecular Genetics of Von Willebrand Factor SecretionR01HL172780 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Karl C Desch · 2024 to 2026
$1.8M
NHLBI NIH HHS R01 HL172780
6 · The paper itself

Abstract

Background: The plasma protein histidine-rich glycoprotein (HRG) interacts with multiple plasma ligands with various roles in coagulation, immunity, and angiogenesis. Through its inhibition of factor XIIa, HRG regulates the contact pathway of blood coagulation. Plasma HRG concentrations are highly heritable and vary widely, which may impact HRG function. Objectives: To determine the genetic factors contributing to HRG variability. Methods: Plasma HRG concentrations were measured in a healthy sibling cohort of 1152 subjects and a second healthy cohort of 2304 individuals of Irish descent. We performed genome-wide association study and meta-analysis on the European subset of these cohorts. Using the sibling subset of the 2 cohorts ( Results: Narrow-sense heritability was estimated at 69%. Meta-analysis identified an association between HRG concentrations and 2 independent signals at the Conclusion: The results of this genome-wide association study, investigating HRG concentration variation in a healthy population, provide new insights into the genetic control of circulating HRG concentrations and generate data for colocalization and Mendelian randomization studies.

Indexed as

complex traitsgenetic linkagegenome-wide association studyhistidine-rich glycoproteinpartial thrompoplastin timethrombophilia

Identifiers

PMID40756183
PMCPMC12314372

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.