Evidence map›Paper›PMID 40756339›Full record

ArticleJournal of oral microbiology2025

Single-cell RNA sequencing using split-pool barcoding reveals transcriptional heterogeneity in

Eun-Young Jang, Seok Bin Yang, Jeewan Chun, Kyu Hwan Kwack, Sang-Wook Kang, Jae-Hyung Lee, Ji-Hoi Moon

Abstract read
In one paragraph

Article in Journal of oral microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eun-Young JangDepartment of Oral Microbiology, College of Dentistry, Kyung Hee University, Seoul, Republic of Korea.
Seok Bin YangDepartment of Oral Microbiology, College of Dentistry, Kyung Hee University, Seoul, Republic of Korea.
Jeewan ChunDepartment of Oral Microbiology, College of Dentistry, Kyung Hee University, Seoul, Republic of Korea.
Kyu Hwan KwackDepartment of Oral Microbiology, College of Dentistry, Kyung Hee University, Seoul, Republic of Korea.
Sang-Wook KangDepartment of Oral and Maxillofacial Pathology, College of Dentistry, Kyung Hee University, Seoul, Republic of Korea.
Jae-Hyung LeeDepartment of Oral Microbiology, College of Dentistry, Kyung Hee University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-5085-6988
Ji-Hoi MoonDepartment of Oral Microbiology, College of Dentistry, Kyung Hee University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0003-0286-5297

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Materials and Methods: We applied split-pool barcoding-based single-cell RNA sequencing to profile gene expression in 1,942 individual Results: We identified six transcriptionally distinct clusters, with the two largest accounting for 72.7% of the population. Minor clusters exhibited signatures related to stress responses, metabolism, membrane transport, and DNA regulation. Sub-clustering of major populations revealed rare subgroups, including one enriched for genes involved in iron acquisition, proteolysis, and transport. Conclusions: This study presents the first single-cell transcriptomic map of

Indexed as

bacterial gene expressionPorphyromonas gingivalisRNA sequencingsingle-cell analysissplit-pool barcoding

Identifiers

PMID40756339
PMCPMC12315123

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.