Evidence map›Paper›PMID 40756344›Full record

ReviewTheranostics2025

New insights into acute ischemic stroke from the perspective of spatial omics.

Xinpeng Deng, Mingyue Zhao, Enhao Zhang, Liangzhe Wei, Xiang Gao, Dong Zhang, Yi Huang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinpeng DengNingbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Mingyue ZhaoNingbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Enhao ZhangNingbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Liangzhe WeiNingbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Xiang GaoNingbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Dong ZhangDepartment of Neurosurgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Yi HuangNingbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute ischemic stroke (AIS) is a common cerebrovascular disease characterized by high incidence and disability rates, placing a significant burden on global healthcare systems. Various cell types, including microglia, astrocytes, oligodendrocytes, and peripheral immune cells, interact in the pathological process of AIS, profoundly influencing the disease's prognosis. This review, for the first time, summarizes the biological functions and interaction mechanisms of microglia, astrocytes, oligodendrocytes, their subgroups, and infiltrating peripheral immune cells at different time points and spatial distributions following AIS, from the perspective of spatial single-cell omics. Spatial transcriptomics technology combines high-resolution gene expression information with tissue spatial architecture, enabling researchers to precisely identify the spatial distribution and dynamic crosstalk between CNS-resident cells and peripheral immune cell subsets. Intervening in the interactions between cell subgroups or different cell types and effectively targeting specific subgroups in the target area, may help minimize the negative effects of harmful subsets while enhancing the functions of beneficial ones. The application of spatial single-cell transcriptomics provides an unprecedented perspective for understanding the complex intercellular interactions following stroke, laying the foundation for precision interventions and targeted therapies.

Indexed as

Brain IschemiaIschemic StrokeAnimalsAstrocytesGene Expression ProfilingHumansMicrogliaOligodendrogliaSingle-Cell AnalysisTranscriptomeacute ischemic strokeimmune inflammation.microgliaperipheral immune cellsspatial omics

Identifiers

PMID40756344
PMCPMC12316105

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.