Evidence mapPaperPMID 40756604Full record

ReviewFrontiers in cardiovascular medicine2025

Key inflammatory players for infarcted mass and cardiac remodeling after acute myocardial infarction.

Francisco A H Fonseca, Carolina N França, Henrique A R Fonseca, Andrey J Serra, Maria C Izar

Abstract readReview
In one paragraph

Review in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Francisco A H FonsecaDepartment of Medicine, Escola Paulista de Medicina da Universidade Federal de São Paulo, São Paulo, Brazil.
Carolina N FrançaPost-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo, Brazil.
Henrique A R FonsecaInstituto Israelita de Ensino e Pesquisa, Albert Einstein Israelite Hospital, São Paulo, Brazil.
Andrey J SerraDepartment of Medicine, Escola Paulista de Medicina da Universidade Federal de São Paulo, São Paulo, Brazil.
Maria C IzarDepartment of Medicine, Escola Paulista de Medicina da Universidade Federal de São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis has been defined as an inflammatory disease. As observed during acute infections, excess inflammatory activity is associated with disease severity and mortality. After myocardial infarction, several waves of inflammatory cells play a crucial role in infarct size and cardiac remodeling. In the short and long term, subtypes of inflammatory cells and cytokines released orchestrate the healing and stability of coronary disease. In recent years, some anti-inflammatory therapies have been shown to reduce the residual cardiovascular risk. Furthermore, some medications for treating risk factors and adoption of healthy lifestyle have decreased inflammatory markers and cardiovascular outcomes. In this complex network of possibilities, multiple interventions and not just on specific cell type or cytokine may provide better results. Finally, mild or moderate inflammatory activity appears necessary for better recovery and survival after acute myocardial infarction.

Indexed as

B cellsC-reactive proteincytokinesdendritic cellsmacrophages/monocytesmicrobiotaneutrophilsT cells

Identifiers

PMID40756604
PMCPMC12313495

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.