ArticleNature and science of sleep2025
Associations Among Obstructive Sleep Apnea, Thyroid Function and Morphology Changes.
Article in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Sex-specific associations between obstructive sleep apnea and thyroid hormone sensitivity in euthyroid adults.Biology of sex differences · 2026Article
- Development and Internal Evaluation of a Nomogram for Clinically Significant Depressive Symptoms in Obstructive Sleep Apnea-Hypopnea Syndrome.Nature and science of sleep · 2026Article
- Obstructive sleep apnea as a modifier of endocrine toxicities associated with immune checkpoint inhibitors in lung cancer.Frontiers in immunology · 2026Review
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study unveils the complex interplay among obstructive sleep apnea (OSA), thyroid function, and morphological changes. Methods: Data from 1,102 patients were collected retrospectively from the Department of Otorhinolaryngology-Head and Neck Surgery of the Second Affiliated Hospital of Xi'an Jiaotong University from 2012 to 2023. The patients were divided into severe and non-severe OSA groups according to their polysomnography results. The data were analyzed by sex and age stratification. Results: Serum free triiodothyronine (FT3), total triiodothyronine (TT3), and reverse triiodothyronine (RT3) were higher in severe OSA group in the total population ( Conclusion: Our study demonstrates a significant association between thyroid function/morphology and OSA, with distinct sex- and age-related differences. Reduced RI in severe OSA suggests its clinical utility in assessing vascular health. Increased thyroid volume and isthmus length in severe OSA may reflect ITA-related changes. These findings support our prior observations of rising thyroid hormone levels with OSA progression and highlight the need for sex- and age-stratified analyses. Integrated evaluation of thyroid function and morphology is essential for understanding OSA-thyroid pathophysiology.
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