Evidence mapPaperPMID 40757165Full record

ArticleBurns & trauma2025

Extracellular vesicles and their mimetics: clinical application prospects in medical aesthetics.

Zixuan Sun, Jiali Li, Zhijing Wu, Jiaxin Zhang, Tangrong Wang, Yuzhou Zheng, XueZhong Xu, Wei Ding, Hui Qian, Yulin Tan

Abstract read
In one paragraph

Article in Burns & trauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zixuan SunDepartment of General Surgery, Wujin Hospital Affiliated with Jiangsu University, No. 2 Yongning North Road, Jiangsu, Changzhou 213017, China.
Jiali LiJiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, No. 301 Xuefu Road, Jiangsu, Zhenjiang 212013, China.
Zhijing WuJiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, No. 301 Xuefu Road, Jiangsu, Zhenjiang 212013, China.
Jiaxin ZhangJiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, No. 301 Xuefu Road, Jiangsu, Zhenjiang 212013, China.
Tangrong WangJiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, No. 301 Xuefu Road, Jiangsu, Zhenjiang 212013, China.
Yuzhou ZhengJiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, No. 301 Xuefu Road, Jiangsu, Zhenjiang 212013, China.
XueZhong XuDepartment of General Surgery, Wujin Hospital Affiliated with Jiangsu University, No. 2 Yongning North Road, Jiangsu, Changzhou 213017, China.
Wei DingDepartment of General Surgery, Wujin Hospital Affiliated with Jiangsu University, No. 2 Yongning North Road, Jiangsu, Changzhou 213017, China.
Hui QianJiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, No. 301 Xuefu Road, Jiangsu, Zhenjiang 212013, China.
Yulin TanDepartment of General Surgery, Wujin Hospital Affiliated with Jiangsu University, No. 2 Yongning North Road, Jiangsu, Changzhou 213017, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The persistent desire for beauty has fueled the rapid development of medical aesthetics. Multiple approaches, including cosmetics, drugs, and cell therapies, have been developed to improve skin conditions. However, none of these methods achieves the intended outcomes and may produce adverse repercussions. Consequently, it is crucial to develop effective and safe therapies to promote skin repair and regeneration. Extracellular vesicles (EVs) are cell-derived, lipid bilayer-encapsulated nanoparticles containing multiple active components. There is now strong evidence that EV therapies can improve skin barrier function, reduce scarring, inhibit aging and pigmentation, and suppress hair loss, highlighting the potential for cosmeceutical development based on EVs. This review summarizes the latest applications of natural EVs, preconditioned and engineered EVs, and EV mimetics in medical aesthetics. Additionally, the article discusses advanced delivery strategies for EVs and the commercial prospects of EVs and provides insights into present security concerns, regulations, and the field's future directions.

Indexed as

Commercial landscapeCosmeceuticalExtracellular vesicle mimeticsExtracellular vesiclesMedical aesthetics

Identifiers

PMID40757165
PMCPMC12315540

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.