Evidence map›Paper›PMID 40757475›Full record

ArticleAging cell2025

Sex-Specific Aging Patterns of Gut Microbiota in Urban Chinese Adults: Guild-Based Analysis and Implications for Healthy Aging.

Jiongxing Fu, Wanghong Xu, Danxia Yu, Yu Jiang, Lei Wang, Hui Cai, Qinghua Xia, Xiao-Ou Shu, Wei Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiongxing FuDepartment of Epidemiology, NHC Key Laboratory for Health Technology Assessment, Fudan University School of Public Health, Shanghai, China.
Wanghong XuDepartment of Epidemiology, NHC Key Laboratory for Health Technology Assessment, Fudan University School of Public Health, Shanghai, China.ORCID 0000-0003-2045-2218
Danxia YuDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Yu JiangChangning District Center for Disease Control and Prevention (Health Supervision Institute), Shanghai, China.
Lei WangDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Hui CaiDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Qinghua XiaChangning District Center for Disease Control and Prevention (Health Supervision Institute), Shanghai, China.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-1226-070X

Funding

Translational Analysis CoreP30DK058404 · VANDERBILT UNIVERSITY MEDICAL CENTER · 2002 to 2025
$4.9M
CANCER RISK REDUCTION AND DIET--A COHORT STUDY OF WOMENR01CA070867 · VANDERBILT UNIVERSITY · 1996 to 2005
$2.8M
Cohort Study of Cancer inhibitory Factors in MenR01CA082729 · VANDERBILT UNIVERSITY · 2001 to 2005
$2.3M
National Natural Science Foundation of China 81773504NCI NIH HHS R01 CA070867NCI NIH HHS R01 CA082729NIDDK NIH HHS P30 DK058404Three-Year Public Health Action Plan of Shanghai GWVI-11.1-22Three-Year Public Health Action Plan of Shanghai GWVI-11.2-XD05
6 · The paper itself

Abstract

Gut microbial stability typically decreases with physiological aging. This decline may vary between sexes and can potentially be mitigated by adopting a healthy lifestyle. Microbial guilds, defined as functionally coherent groups of bacteria, may serve as meaningful ecological indicators of aging. This study included 2944 participants aged 51-89 years from the Shanghai Men's and Women's Health Studies. Using 16S rRNA gene sequencing and a guild-based approach, we evaluated the associations between gut microbiota and age in 1353 relatively healthy individuals. We found that women demonstrated a decline in the Chao1 index, an increase in Pielou evenness, and a remarkable shift in Bray-Curtis distance, whereas men exhibited an increase in Bray-Curtis uniqueness. Of the 45 age-related guilds identified, 16 (8 in men and 10 in women) were considered potential aging biomarkers (p

Indexed as

AgingGastrointestinal MicrobiomeHealthy AgingAgedAged, 80 and overChinaEast Asian PeopleFemaleHumansMaleMiddle AgedRNA, Ribosomal, 16SSex FactorsUrban PopulationRNA, Ribosomal, 16Sagingchronic diseasegastrointestinal microbiomehealthy lifestylesex characteristics

Identifiers

PMID40757475
PMCPMC12507401

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.