Evidence map›Paper›PMID 40757804›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Radical Borylation of Alkyl Bromides by Photoinduced Halogen-Atom Transfer.

Cullen R Schull, Matthew J McGill, Ángel Renteria-Gómez, Poulami Mukherjee, Samuel B Tyndall, Aaron H Shoemaker, Michael R Wasielewski, Osvaldo Gutierrez, Karl A Scheidt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Radical Borylation of Alkyl Bromides by Photoinduced Halogen-Atom Transfer.Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cullen R Schull *Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.
Matthew J McGill *Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.
Ángel Renteria-GómezDepartment of Chemistry and Biochemistry, University of California, 607 Charles E. Young Drive, East Los Angeles, Los Angeles, CA, 90095, USA.
Poulami MukherjeeDepartment of Chemistry and Biochemistry, University of California, 607 Charles E. Young Drive, East Los Angeles, Los Angeles, CA, 90095, USA.
Samuel B TyndallDepartment of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.
Aaron H ShoemakerDepartment of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.
Michael R WasielewskiDepartment of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.
Osvaldo GutierrezDepartment of Chemistry and Biochemistry, University of California, 607 Charles E. Young Drive, East Los Angeles, Los Angeles, CA, 90095, USA.
Karl A ScheidtDepartment of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.ORCID https://orcid.org/0000-0003-4856-3569

Funding

New Cooperative Catalysis Concepts for Asymmetric SynthesisR35GM136440 · NIGMS · NORTHWESTERN UNIVERSITY · PI Karl A Scheidt · 2020 to 2026
$2.9M
New Directions in Sustainable Open-Shell Radical C-C Bond Formations Enabled by Merging Modern Computational and Experimental MethodsR35GM137797 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI Osvaldo Gutierrez · 2020 to 2026
$2.7M
NIGMS NIH HHS R35 GM136440NIGMS NIH HHS R35 GM137797NIH HHS R35GM137797Office of Science DE-FG02-99ER14999
6 · The paper itself

Abstract

Alkyl organoboron compounds are versatile synthons in organic synthesis, enabling rapid access to a variety of carbon─carbon and carbon-heteroatom bonds. As such, strategies to efficiently access carbon-boron bonds from simple chemical feedstocks are highly desirable. The radical borylation of alkyl bromides presents an attractive approach. However, the activation of alkyl bromides typically requires strong reductants or transition-metal catalysts. Herein, we report a metal-free radical borylation strategy of various alkyl bromides utilizing a photoinduced silyl radical to mediate a halogen-atom transfer process. This method demonstrates broad utility and functional group tolerance among various primary, secondary, and tertiary unactivated alkyl bromides and can facilitate the functionalization of pharmaceutically relevant motifs. Mechanistic and computational studies support a radical-chain pathway involving a silyl radical-mediated halogen-atom transfer.

Indexed as

AlkylsBorylationHalogensPhotochemistryRadicals

Identifiers

PMID40757804
PMCPMC12435432

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.