ReviewJournal of neurochemistry2025
Shared Mechanisms in Dementia and Depression: The Modulatory Role of Physical Exercise.
Review in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Physical exercise as a therapeutic strategy in animal models of Alzheimer's disease: Molecular, behavioral, and histopathological evidence.Biochemistry and biophysics reports · 2026Review
- Depressive and insomnia symptoms and incident dementia risk: A 12-year study in U.S. older adults.Journal of affective disorders · 2026Article
- Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Depression and aging: insights from brain age prediction models.Psychological medicine · 2026Article
- Adaptogenic and Neuroprotective Effects of the Thai Herbal Formula AYW-KK-04 Against Chronic Stress-Induced Cognitive Impairment.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Research progress on plant-derived bioactive compounds and late-life depression: from neuroprotective mechanisms to dietary patterns.Frontiers in nutrition · 2026Review
- Prevention of cognitive decline and dementia: Current evidence on lifestyle factors and dietary patterns.EXCLI journal · 2026Review
- Functional exercise, fear of recurrence, and sleep quality: a longitudinal path analysis of quality of life in postoperative breast cancer patients.Frontiers in oncology · 2026Article
- Shared Mechanisms in Dementia and Depression: The Modulatory Role of Physical Exercise.Journal of neurochemistry · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Dementia and depression are two prevalent disorders that warrant significant attention due to their high prevalence and substantial contribution to the global burden of disease. Depression has a high incidence in the elderly and is considered a risk factor for the development of dementia, being a promising target for dementia prevention strategies. Additionally, dementia and depression share common mechanisms through which they manifest pathologically. This review addresses the potential shared mechanisms between dementia and depression, including hypothalamic-pituitary-adrenal (HPA) axis dysfunction, brain atrophy (mainly hippocampus and prefrontal cortex), cognitive decline, and neuroinflammation. It also explores the therapeutic potential of physical exercise in modulating these shared pathways, highlighting its role as a non-pharmacological intervention for the treatment and prevention of both disorders. The review also explores the muscle-brain crosstalk and the intracellular pathways through which physical exercise exerts its effects.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.