Evidence map›Paper›PMID 40757876›Full record

ArticleHuman brain mapping2025

Cerebral Amyloid Deposition With

Zhigeng Chen, Hai-Long He, Zhongyuan Qi, Sheng Bi, Hongwei Yang, Xuanyu Chen, Tianze Xu, Zi-Bing Jin, Shaozhen Yan, Jie Lu

Abstract read
In one paragraph

Article in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Cerebral Amyloid Deposition WithHuman brain mapping · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhigeng ChenDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-1675-5606
Hai-Long HeBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Zhongyuan QiDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Sheng BiDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Hongwei YangDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Xuanyu ChenBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Tianze XuBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Zi-Bing JinBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Shaozhen YanDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-0315-7930
Jie LuDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.ORCID 0000-0003-0425-3921

Funding

National Natural Science Foundation of China 62333002National Natural Science Foundation of China 82102010National Natural Science Foundation of China 82125007National Natural Science Foundation of China 82394434
6 · The paper itself

Abstract

Alzheimer's disease (AD) is accompanied by alterations in retinal vascular density (VD), but the mechanisms remain unclear. This study investigated the relationship among cerebral amyloid-β (Aβ) deposition, VD, and cognitive decline. We enrolled 92 participants, including 47 AD patients and 45 healthy control (HC) participants. VD across retinal subregions was quantified using deep learning-based fundus photography, and cerebral Aβ deposition was measured with

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesCerebral CortexCognitive DysfunctionRetinal VesselsAgedAged, 80 and overAniline CompoundsEthylene GlycolsFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyAmyloid beta-PeptidesAniline CompoundsEthylene GlycolsflorbetapirAlzheimer's diseaseamyloid‐βfundus photographypositron emission tomographyretinavascular density

Identifiers

PMID40757876
PMCPMC12320289

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.