Evidence map›Paper›PMID 40757944›Full record

ArticleAnnals of medicine2025

Separate aneurysmal neck is essential for analyzing hemodynamics and predicting instability of intracranial aneurysms.

Yudi Tang, Haining Wei, Zihao Zhang, Mingzhu Fu, Junqiang Feng, Zhixin Li, Xinke Liu, Yue Wu, Jinyuan Zhang, Ting Chen and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yudi TangDepartement of Neurosurgery, Beijing Tiantan Hospital and Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Haining WeiDepartment of Biomedical Engineering, Medical School, Center for Biomedical Imaging Research, Tsinghua University, Beijing, China.
Zihao ZhangState Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Mingzhu FuDepartment of Biomedical Engineering, Medical School, Center for Biomedical Imaging Research, Tsinghua University, Beijing, China.
Junqiang FengDepartment of Neurosurgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Zhixin LiState Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Xinke LiuDepartement of Neurosurgery, Beijing Tiantan Hospital and Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Yue WuState Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Jinyuan ZhangState Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Ting ChenDepartment of Radiology, International Exemplary Cooperation Base of Precision Imaging for Diagnosis and Treatment, Guizhou Provincial People's Hospital, Guizhou, China.
Wei YouDepartement of Neurosurgery, Beijing Tiantan Hospital and Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Rong XueState Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Aihua LiuDepartement of Neurosurgery, Beijing Tiantan Hospital and Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Yan ZhuoState Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Yuhua JiangDepartement of Neurosurgery, Beijing Tiantan Hospital and Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Youxiang LiDepartement of Neurosurgery, Beijing Tiantan Hospital and Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Rui LiDepartment of Biomedical Engineering, Medical School, Center for Biomedical Imaging Research, Tsinghua University, Beijing, China.
Peng LiuDepartement of Neurosurgery, Beijing Tiantan Hospital and Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHemodynamics influence aneurysm growth and rupture through injury and inflammation mediated by both high and low wall shear stress (WSS). The parent artery configuration (bifurcation or sidewall) significantly impacts hemodynamics at the aneurysmal neck, yet this factor has been overlooked in hemodynamics-based aneurysm risk assessment. This study aimed to evaluate the effect of parent artery type on the relationship between aneurysmal neck WSS and inflammation.

methodsFifty-six unruptured intracranial aneurysms from 55 participants were prospectively analyzed. Imaging was performed using 7.0 T MRI. The aneurysm-to-pituitary stalk contrast ratio (CRstalk) quantified aneurysm inflammation and instability. Hemodynamic parameters were assessed using four-dimensional (4D) flow MRI.

resultsThe hemodynamic characteristics of the aneurysmal neck, as related to CRstalk, differed from those of the whole aneurysm. Most aneurysmal necks exhibited a significant negative correlation between WSS and CRstalk in the bifurcation group (

conclusionThe location of an aneurysm (bifurcation or sidewall) significantly influences the correlation between WSS and CRstalk specifically at the aneurysmal neck. Regional hemodynamic assessment of the neck provides a novel approach for improving rupture risk prediction.

Indexed as

Aneurysm, RupturedHemodynamicsIntracranial AneurysmAdultAgedFemaleHumansMagnetic Resonance AngiographyMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesStress, Mechanical4D flow MRI7T MRIaneurysmaneurysmal wall enhancementhemodynamicsunruptured

Identifiers

PMID40757944
PMCPMC12322982

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.