ArticleAmerican journal of physiology. Heart and circulatory physiology2025
Hypertensive BPH/2J mice exhibit sex-specific heart failure progression and late-life microvascular rarefaction.
Laena Pernomian, Emily W Waigi, Juliana M Parente, Cameron G McCarthy, Camilla F Wenceslau
Abstract read
In one paragraphArticle in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
5 authors.
Laena PernomianDepartment of Cell Biology and Anatomy, School of Medicine, Cardiovascular Translational Research Center, University of South Carolina, Columbia, South Carolina, United States.ORCID 0000-0003-3930-0919 Emily W WaigiDepartment of Cell Biology and Anatomy, School of Medicine, Cardiovascular Translational Research Center, University of South Carolina, Columbia, South Carolina, United States.
Juliana M ParenteDepartment of Cell Biology and Anatomy, School of Medicine, Cardiovascular Translational Research Center, University of South Carolina, Columbia, South Carolina, United States.
Cameron G McCarthyDepartment of Cell Biology and Anatomy, School of Medicine, Cardiovascular Translational Research Center, University of South Carolina, Columbia, South Carolina, United States.ORCID 0000-0002-1380-779X Camilla F WenceslauDepartment of Cell Biology and Anatomy, School of Medicine, Cardiovascular Translational Research Center, University of South Carolina, Columbia, South Carolina, United States.ORCID 0000-0002-0815-3568 Funding
South Carolina IDeA Networks of Biomedical Research (SC INBRE V)P20GM103499 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI EDIE C GOLDSMITH · 2012 to 2026
$61.0MTargeting early ceramide elevation in pre-symptomatic eczemaP20GM103641 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI NAGARKATTI, PRAKASH S · 2012 to 2023
$20.7MFormyl peptide receptor activation induces vascular plasticity and remodeling inhypertensionR01HL149762 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WENCESLAU, CAMILLA FERREIRA · 2021 to 2025
$1.9MAutophagy regulates β-hydroxybutyrate synthesis to prevent hypertension-associated premature vascular agingR00HL151889 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MCCARTHY, CAMERON · 2022 to 2024
$742kCerebrovascular O-GlcNAcylation Worsens Diabetes-associated Neurovascular Injury and Recovery Post-strokeR56HL169223 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MCCARTHY, CAMERON · 2024 to 2024
$512kReprogramming endothelial cells to prevent and treat Alzheimer disease (AD) and HypertensionR21AG085331 · NIA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI WENCESLAU, CAMILLA FERREIRA · 2024 to 2025
$410kAlzheimer 's Association (AA) AARG-NTF-23-1145090HHS | National Institutes of Health (NIH) P20GM103641-Pilot ProjectHHS | National Institutes of Health (NIH) R00HL151889HHS | National Institutes of Health (NIH) R01HL149762HHS | National Institutes of Health (NIH) R21AG085331-01HHS | National Institutes of Health (NIH) R56HL169223NHLBI NIH HHS R00 HL151889NHLBI NIH HHS R01 HL149762NIA NIH HHS R21 AG085331NIGMS NIH HHS P20 GM103499NIGMS NIH HHS P20 GM103641USC | Office of the Vice President for Research, University of South Carolina
6 · The paper itselfAbstract
Heart failure (HF) involves structural and functional impairments in ventricular filling or blood ejection, and it is a growing health burden in the United States. Sex differences in HF with mildly reduced ejection fraction (HFmrEF) have been observed, and this condition is exacerbated by endothelial cell (EC) microvascular rarefaction. HF with preserved ejection fraction (HFpEF) is more prevalent in women, with hypertension being the major risk factor. However, the mechanisms by which hypertension contributes to HFpEF development remain poorly understood. We hypothesized that male hypertensive BPH/2J (blood pressure high) mice develop HFmrEF later in life with cardiac EC rarefaction, whereas female hypertensive BPH/2J mice show HFpEF. Male and female BPN/3J (blood pressure normal or control) and BPH/2J mice were assessed for blood pressure (6 wk and 1.5 yr of age). Cardiac function was assessed by echocardiography. Cardiac EC density and stem-cell antigen-1 (SCa1)
Indexed as
Heart FailureHypertensionMicrovascular RarefactionAge FactorsAnimalsBlood PressureDisease Models, AnimalDisease ProgressionEndothelial CellsFemaleMaleMiceSex FactorsStroke VolumeVentricular Function, LeftHeart failure with mildly reduced ejection fractionheart failure with preserved ejection fractionmicrovascular rarefactionstem-cell antigen-1 progenitor cells
Identifiers
PMID40758569
PMCPMC12372015
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390