Uric acid mediates the association of alpha-1 acid glycoprotein with gallstones in adult women in the United States.

Xingxing Liu, Kang Li, Xiaolong Ying, Yu Zhao, Youxiang Chen, Chunyan Zeng, Yixing Luo

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Association between alpha-1-acid glycoprotein and serum uric acid in young and middle-aged US women: A cross-sectional study on the mediating role of the triglyceride-glucose index.Medicine · 2026
Article

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5 · Who and what money

Authors and funding

7 authors.

Xingxing Liu *Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Kang Li *Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Xiaolong Ying *Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Yu ZhaoDivision of Gastroenterology and Hepatology, Mayo Clinic, 55905, Rochester, Minnesota, USA.

Youxiang ChenDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Chunyan Zeng *Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. zengcy896@ncu.edu.cn.

Yixing Luo *Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. ndyfy05032@ncu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gallstones are a common biliary disorder whose pathogenesis may involve alpha-1-acid glycoprotein (AGP), an acute phase inflammatory protein. Serum uric acid (SUA) is the end product of purine metabolism and is associated with a variety of chronic diseases. We conducted a cross-sectional analysis of 1,652 adult women from the 2017-2020 NHANES database to explore the association between AGP levels and gallstone risk and the potential mediating role of SUA. We used multivariate logistic regression, restricted cubic spline curves, subgroup analyses, and causal mediation analyses to evaluate the association between serum AGP levels and gallstone risk.Serum AGP levels were significantly associated with gallstone risk. After correcting for covariates, the highest AGP quartile (≥ 0.950 g/L) was associated with a 1.72-fold higher risk of gallstones compared to the lowest quartile (≤ 0.629 g/L) (OR = 2.72,95% CI: 1.31-5.65; p = 0.014). Subgroup analyses revealed stronger associations in non-Hispanic whites, low-income individuals, and smokers. SUA partially mediated the AGP-gallstone relationship, accounting for 14.76% of the total effect. This study found that AGP levels were significantly associated with gallstone risk in US adult women, and serum uric acid played a mediating role. Future research should further investigate the causal relationship and its applicability in different populations.

Indexed as

GallstonesOrosomucoidUric AcidAdultAgedCross-Sectional StudiesFemaleHumansMiddle AgedNutrition SurveysRisk FactorsUnited StatesOrosomucoidUric AcidAlpha-1-acid glycoproteinCross-sectional studyGallstonesIntermediary effectUric acid

Identifiers

PMID40760000

DOI10.1038/s41598-025-13208-8

PMCPMC12322271

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.