ArticleNature neuroscience2025
The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation.
Abstract read
In one paragraph
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuroplasticity and recovery of the brain affected by substance use disorder: multilevel mechanisms and new therapeutic strategies (2020-2025).Frontiers in molecular neuroscience · 2026Pooled it
- Deconstruction of lysergic acid diethylamide.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Psilocybin enhances sociability only in altered behavioural state and does not need an awake experience to be effective.Nature communications · 2026Article
- Role of β-Arrestin2 Signaling in Neuropharmacological Effects of Psychedelic Drugs.ACS chemical neuroscience · 2026Article
- Psychedelic drug action at dendrites is gated by behavioral state and serotonin receptors.bioRxiv : the preprint server for biology · 2026Article
- Dissociating the Hallucinogenic and Neuroplastic Effects of Psilocybin.bioRxiv : the preprint server for biology · 2026Article
- The working lives of neuronal 5-HTRSC chemical biology · 2026Review
- Mechanistic insights toward dissociating therapeutic from psychedelic effects: bridging the gap between psychedelic research and mental health care.Translational psychiatry · 2026Review
- Activity of Nonhallucinogenic Ibogalogs on Chemotherapy-Induced Peripheral Neuropathic Pain in Mice.ACS chemical neuroscience · 2026Article
- Dually Acting Ligands Targeting Serotonin Receptors: Implications in CNS Disorders.Journal of medicinal chemistry · 2026Review
- Ibogalogs induce antiseizure activity in rodents by a mechanism involving 5-HTBiochemical pharmacology · 2026Article
- A Single Dose of a Psychedelic Drug Repairs Prefrontal Cortex Synaptic Physiology in a Mouse Model of Prenatal Alcohol Exposure.Brain and behavior · 2026Article
- Esketamine Nasal Spray: Mechanism of Action, Clinical, and Translational Science.Clinical and translational science · 2026Review
- Ibogalogs Activate the 5-HTNeurochemical research · 2026Article
- Beyond the Genomic Storm: Evaluating Tabernanthalog as a Potential Scaffold for Silent Neuroplasticity and Broad-Spectrum Therapy.International journal of molecular sciences · 2026Review
- Ischemia-Induced Neurodegeneration in Glaucoma: Mechanistic Insights and Translational Opportunities for Psychoplastogen-Based Therapies.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Old Dog, New Tricks: Ibogaine and Its Analogs as Potential Neurotherapeutics.Journal of medicinal chemistry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors.
Isak K Aarrestad *Neuroscience Graduate Program, University of California, Davis, Davis, CA, USA.
Lindsay P Cameron *Neuroscience Graduate Program, University of California, Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-8420-7898
Ethan M FentonNeuroscience Graduate Program, University of California, Davis, Davis, CA, USA.
Austen B CaseyDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-4670-851X
Daniel R RijsketicDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2197-0730
Seona D PatelDepartment of Chemistry, University of California, Davis, Davis, CA, USA.
Rohini SambyalDepartment of Chemistry, University of California, Davis, Davis, CA, USA.
Shane B JohnsonDepartment of Psychiatry and Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-3425-9726
Calvin LyDepartment of Chemistry, University of California, Davis, Davis, CA, USA.
Jayashri ViswanathanDepartment of Chemistry, University of California, Davis, Davis, CA, USA.
Eden V BarraganNeuroscience Graduate Program, University of California, Davis, Davis, CA, USA.
Stephanie A LozanoNeuroscience Graduate Program, University of California, Davis, Davis, CA, USA.
Nicolas SebanNeuroscience Graduate Program, University of California, Davis, Davis, CA, USA.
Hongru HuIntegrative Genetics and Genomics Graduate Program, University of California, Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0003-0497-4796
Noel A PowellDelix Therapeutics, Inc., Bedford, MA, USA.
Milan ChytilDelix Therapeutics, Inc., Bedford, MA, USA.
Retsina MeyerDelix Therapeutics, Inc., Bedford, MA, USA.
David RoseExpressive Neuroscience, LLC, Syracuse, NY, USA.
Chris HempelExpressive Neuroscience, LLC, Syracuse, NY, USA.
Eric OlsonExpressive Neuroscience, LLC, Syracuse, NY, USA.
Hanne D HansenNeurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5564-7627
Clara A MadsenNeurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-3240-0223
Gitte M KnudsenNeurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1508-6866
Chase ReddTranslucence Biosystems, Inc., Irvine, CA, USA.
Damian G WheelerTranslucence Biosystems, Inc., Irvine, CA, USA.
Nathaniel GuanzonTranslucence Biosystems, Inc., Irvine, CA, USA.
Jessie MuirCenter for Neuroscience, University of California, Davis, Davis, CA, USA.
Joseph J HennesseyDepartment of Cell Biology, Neurobiology and Anatomy, Neuroscience Research Center and Cancer Center, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0003-0981-4695
Gerald QuonDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-1716-0153
John D McCorvyDepartment of Cell Biology, Neurobiology and Anatomy, Neuroscience Research Center and Cancer Center, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0001-7555-9413
Sunil P GandhiTranslucence Biosystems, Inc., Irvine, CA, USA.
Kurt RasmussenDelix Therapeutics, Inc., Bedford, MA, USA.
Conor ListonDepartment of Psychiatry and Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-1639-5401
John A GrayInstitute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-7287-0748
Boris D HeifetsDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1474-0379
Alex S NordInstitute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0003-4259-7514
Christina K KimInstitute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-1466-7098
David E OlsonInstitute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA, USA. deolson@ucdavis.edu.ORCID http://orcid.org/0000-0002-4517-0543
Funding
Training CoreP50DA042012 · NIDA · STANFORD UNIVERSITY · PI Karl A. Deisseroth, Lisa Giocomo · 2017 to 2026
$27.1MRodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SIMON, TONY J · 2013 to 2019
$8.5MRegulation of prefrontal cortical circuit function and reward-seeking behavior by stress-induced dendritic spine remodelingR01MH118451 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI Joshua Levitz, Conor M Liston · 2019 to 2026
$5.5MFunctional Elucidation of the Sequence-Encoded Regulatory Activity of Enhancers in Vivo in the BrainR35GM119831 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Alexander Nord · 2016 to 2026
$3.9MMolecular Mechanisms of G protein-coupled Receptor Biased SignalingR35GM133421 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI John D McCorvy · 2019 to 2026
$3.3MRapid Evaluation of Neuronal Activity in the Intact Whole Brain at Single Cell ResolutionR44MH119989 · NIMH · TRANSLUCENCE BIOSYSTEMS, INC. · PI WHEELER, DAMIAN G. · 2021 to 2023
$2.9MHigh-throughput Identification of Non-hallucinogenic Psychoplastogens for Treating AddictionR01DA056365 · NIDA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI David E Olson · 2022 to 2026
$2.7MActivity-dependent probes for spatially-defined proteomicsDP2MH136588 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Christina Kim · 2023 to 2026
$2.4MLearning, Memory, and Plasticity (LaMP) Training ProgramT32MH112507 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Karen Zito · 2017 to 2026
$2.4MLinking genetics to cellular behavior and disease via multimodal data integrationDP2MH129987 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI QUON, GERALD · 2021 to 2024
$2.3MMapping Neural Circuit Activity Mediating MDMA's Prosocial EffectR01MH130591 · NIMH · STANFORD UNIVERSITY · PI Boris Dov Heifets · 2023 to 2026
$2.3MPredoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2MGouvernement du Canada | Instituts de Recherche en Santé du Canada | CIHR Skin Research Training Centre (Skin Research Training Centre) 202210MFE-491520-297096NCRR NIH HHS S10 RR019266NICHD NIH HHS U54 HD079125NIDA NIH HHS P50 DA042012NIDA NIH HHS R01 DA056365NIGMS NIH HHS R01 GM128997NIGMS NIH HHS R35 GM119831NIGMS NIH HHS R35 GM133421NIGMS NIH HHS R35 GM148182NIGMS NIH HHS T32 GM099608NIGMS NIH HHS T32 GM113770NIMH NIH HHS DP2 MH129987NIMH NIH HHS DP2 MH136588NIMH NIH HHS R01 MH118451NIMH NIH HHS R01 MH130591NIMH NIH HHS R44 MH119989NIMH NIH HHS T32 MH112507UC | University of California, Davis (UC Davis) Davis Provost's Undergraduate FellowshipUC | University of California, Davis (UC Davis) Human Genetics Focus Group grantU.S. Department of Health & Human Services | National Institutes of Health (NIH) DP2MH136588U.S. Department of Health & Human Services | National Institutes of Health (NIH) P50DA042012U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01DA056365U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01GM128997U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01MH130591U.S. Department of Health & Human Services | National Institutes of Health (NIH) R35GM119831U.S. Department of Health & Human Services | National Institutes of Health (NIH) R35GM133421U.S. Department of Health & Human Services | National Institutes of Health (NIH) R35GM148182U.S. Department of Health & Human Services | National Institutes of Health (NIH) R44MH119989U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32GM099608U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32GM113770U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32MH112507
Abstract
Nonhallucinogenic psychoplastogens, such as tabernanthalog (TBG), are being developed as potentially safer, more scalable alternatives to psychedelics for promoting neuronal growth and treating various brain conditions. Currently, it is unclear whether 5-hydroxytryptamine 2A (5-HT
Indexed as
Genes, Immediate-EarlyHallucinogensNeuronal PlasticityAnimalsMaleMiceMice, Inbred C57BLRatsReceptors, AMPAReceptor, Serotonin, 5-HT2AReceptor, trkBTOR Serine-Threonine KinasesHallucinogensReceptors, AMPAReceptor, Serotonin, 5-HT2AReceptor, trkBTOR Serine-Threonine Kinases
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.