Evidence map›Paper›PMID 40760244›Full record

ArticleJournal of physiology and biochemistry2025

Sirtuin 1 overexpression in mice preserves insulin and thermogenic responses in subcutaneous inguinal white adipose tissue under proinflammatory conditions.

Patricia Vázquez, Carmen Escalona-Garrido, Nuria Pescador, Ana B Hitos, Daniel González-Moreno, Ángela de Benito-Bueno, Elena Sierra-Filardi, Patricia Boya, Ana Montero-Pedrazuela, Ana Guadaño-Ferraz and 1 more

Abstract read
In one paragraph

Article in Journal of physiology and biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Patricia VázquezInstituto de Investigaciones Biomédicas "Sols-Morreale" (IIBm, CSIC- UAM), Madrid, Spain. pvazquezperez@ucm.es.ORCID http://orcid.org/0000-0003-3763-0391
Carmen Escalona-Garrido *Instituto de Investigaciones Biomédicas "Sols-Morreale" (IIBm, CSIC- UAM), Madrid, Spain.
Nuria Pescador *Instituto de Investigaciones Biomédicas "Sols-Morreale" (IIBm, CSIC- UAM), Madrid, Spain.
Ana B HitosInstituto de Investigaciones Biomédicas "Sols-Morreale" (IIBm, CSIC- UAM), Madrid, Spain.
Daniel González-MorenoInstituto de Investigaciones Biomédicas "Sols-Morreale" (IIBm, CSIC- UAM), Madrid, Spain.
Ángela de Benito-BuenoInstituto de Investigaciones Biomédicas "Sols-Morreale" (IIBm, CSIC- UAM), Madrid, Spain.
Elena Sierra-FilardiDepartamento de Biología Celular y Molecular, Centro de Investigaciones Biológicas Margarita Salas (CIB, CSIC), Madrid, Spain.
Patricia BoyaDepartamento de Biología Celular y Molecular, Centro de Investigaciones Biológicas Margarita Salas (CIB, CSIC), Madrid, Spain.
Ana Montero-PedrazuelaInstituto de Investigaciones Biomédicas "Sols-Morreale" (IIBm, CSIC- UAM), Madrid, Spain.
Ana Guadaño-FerrazInstituto de Investigaciones Biomédicas "Sols-Morreale" (IIBm, CSIC- UAM), Madrid, Spain.
Ángela M ValverdeInstituto de Investigaciones Biomédicas "Sols-Morreale" (IIBm, CSIC- UAM), Madrid, Spain. avalverde@iib.uam.es.ORCID http://orcid.org/0000-0003-1192-9045

Funding

Comunidad de Madrid S2017/BMD-3684MICIU/AEI/10.13039/501100011033/ and by ERDF "A way of making Europe" RTI2018-094052-B-100MICIU/AEI/10.13039/501100011033 and by ERDF/EU PID-2021-122766OB-100
6 · The paper itself

Abstract

Activation of brown adipose tissue (BAT) or subcutaneous adipose tissue (iWAT in mice) is a strategy to regulate metabolic homeostasis. The NAD

Indexed as

Adipose Tissue, WhiteInflammationInsulinSirtuin 1Subcutaneous FatThermogenesisAdipose Tissue, BrownAnimalsInsulin ResistanceLipopolysaccharidesMaleMiceMice, Inbred C57BLMice, TransgenicRAW 264.7 CellsUncoupling Protein 1InsulinLipopolysaccharidesSirt1 protein, mouseSirtuin 1Ucp1 protein, mouseUncoupling Protein 1BrowningInflammationInsulin signalingiWATObesitySIRT1UCP-1

Identifiers

PMID40760244
PMCPMC12738626

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.