Evidence mapPaperPMID 40760249Full record

Trial reportDiabetologia2025

Insulin DEgludec/LIraglutide versus multiple daily insulin injections in the transition from hospital to outpatient management assessed by continuous glucose monitoring: the DELI transition trial.

Ana M Gómez-Medina, Diana C Henao-Carillo, Lina P Villamil-Castañeda, Yaline Gómez-Quesada, Oscar M Muñoz-Velandia, Carlos A Yepes, Salma N Chaim, Carlos E Pertuz-Noriega, Pablo Aschner

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Diabetologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT05767255. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05767255 phase3unknown status

Risk of Hypoglycemia in the Transition From Inpatient to Outpatient Setting. Comparative Study of Basal-bolus Insulin Versus Basal Insulin Plus GLP-1 Analogue

Ran2022Enrolled66Registered outcomes8Posted comparisons0ConditionsDiabetes Mellitus, Type 2 Treated With InsulinArmsinsulin degludec + liraglutide, Insulin Glargine - Insulin Aspart
Open the trial in the graph
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ana M Gómez-MedinaEndocrinology Unit, Pontificia Universidad Javeriana, Bogotá, Colombia. anagomez@javeriana.edu.co.ORCID http://orcid.org/0000-0002-8907-3470
Diana C Henao-CarilloEndocrinology Unit, Pontificia Universidad Javeriana, Bogotá, Colombia.ORCID http://orcid.org/0000-0002-1353-148X
Lina P Villamil-CastañedaEndocrinology Unit, Pontificia Universidad Javeriana, Bogotá, Colombia.
Yaline Gómez-QuesadaEndocrinology Unit, Pontificia Universidad Javeriana, Bogotá, Colombia.
Oscar M Muñoz-VelandiaDepartment of Internal Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia.ORCID http://orcid.org/0000-0001-5401-0018
Carlos A YepesEndocrinology Unit, Pontificia Universidad Javeriana, Bogotá, Colombia.ORCID http://orcid.org/0000-0001-8588-5589
Salma N ChaimSchool of Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia.
Carlos E Pertuz-NoriegaSchool of Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia.
Pablo AschnerSchool of Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia.ORCID http://orcid.org/0000-0002-6860-3620

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AIMS/

objectiveThe aim of the study was to assess the safety profile (defined as the percentage of patients with at least one hypoglycaemic event [more than 15 min with glucose levels <3.0 mmol/l as documented by continuous glucose monitoring] in the first 4 weeks of follow-up) for insulin degludec/liraglutide (IDegLira) compared with multiple daily insulin injections (MDI) during the transition from hospital to an outpatient setting.

methodsThe study was an open-label, randomised, controlled clinical trial comparing IDegLira to MDI after hospital discharge in patients with type 2 diabetes. The study evaluated the percentage of patients with at least one hypoglycaemic event, the hypoglycaemia event density, the time in range (TIR 3.8-10 mmol/l), the time below range (TBR <3.0 or <3.8 mmol/l), and other glycaemic management metrics measured by continuous glucose monitoring.

resultsSixty-four patients were included in the analysis (32 in each group). They had a baseline HbA CONCLUSIONS/

interpretationIDegLira proved to be safer and more effective than MDI for individuals with type 2 diabetes who had suboptimal glycaemic control, aiding in their transition from hospital to outpatient care.

trial registrationClinicaltrials.gov NCT05767255

fundingThis research was funded by a grant from the Asociación Colombiana de Endocrinología, Diabetes y Metabolismo (ACE).

Indexed as

Diabetes Mellitus, Type 2Hypoglycemic AgentsInsulinInsulin, Long-ActingLiraglutideAgedBlood GlucoseBlood Glucose Self-MonitoringContinuous Glucose MonitoringFemaleGlycated HemoglobinHumansHypoglycemiaMaleMiddle AgedOutpatientsBlood GlucoseGlycated HemoglobinHypoglycemic AgentsInsulininsulin degludecInsulin, Long-ActingLiraglutideColombiaHospital to home transitionIDegLiraType 2 diabetes mellitus

Identifiers

PMID40760249
PMCPMC12361261

What Socratic holds

Texttitle and abstract
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.