ArticleImplementation science : IS2025
Maximising Embedded Pharmacists in AGed CAre Medication Advisory Committees (MEGA-MAC): protocol for implementing Australia's new guiding principles for medication management in residential aged care facilities using knowledge brokers and a national quality improvement collaborative.
Article in Implementation science : IS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
backgroundIncomplete or delayed implementation of Guidelines can lead to potentially avoidable medication-related harm. All Australian residential aged care facilities (RACFs) are recommended to have access to a multidisciplinary medication advisory committee (MAC) to provide clinical governance of medication management. The objective of this trial is to evaluate the effectiveness and relative net benefit of using knowledge brokers, supported by a national quality improvement collaborative, to implement Australia's new Guiding Principles for Medication Management in Residential Aged Care Facilities (Guiding Principles).
methodsThe Maximising Embedded Pharmacists in AGed CAre Medication Advisory Committees (MEGA-MAC) trial will be conducted in partnership with RACFs operated by three aged care provider organizations across four states of Australia. The intervention will involve knowledge broker dyads (pharmacist plus a MAC representative [e.g. nurse]) developing, implementing and evaluating RACF-specific local action plans to implement the Guiding Principles in up to 15 RACFs. Knowledge broker dyads will be supported by a national quality improvement collaborative (MEGA-MAC collaborative) comprising clinical experts, implementation scientists and resident and caregiver representatives. An interrupted time series design will be used to assess change over time with three pre-intervention (-6, -3 and 0 months) and three post-intervention assessment time points (+ 3, + 6, + 9 months). The primary outcome will be change in pre/post RACF-level concordance with the Guiding Principles measured using quality indicators (score 0 to 28, higher scores = greater concordance). A net benefit analysis will be conducted to examine the relative costs and benefits of implementing the intervention. DISCUSSION: The MEGA-MAC trial investigates a novel multifactorial knowledge translation strategy to improve the uptake of guidelines and support safe and appropriate use of medication in RACFs. We anticipate that the findings will provide new information on the role of healthcare professionals as knowledge brokers, MACs, and quality improvement collaboratives for effective guideline implementation in RACFs. ETHICS AND DISSEMINATION: Ethics approval obtained from Monash University and Grampians Health Human Research Ethics Committees. Findings will be disseminated through professional and lay media, conference presentations and peer-reviewed publications.
trial registrationAustralian New Zealand Clinical Trial Registry (ANZCTR): ACTRN12624000894594. Registered 22nd July 2024 - Prospectively registered. https://www.anzctr.org.au/ACTRN12624000894594.aspx.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.