ArticleHuman brain mapping2025
Improving the Quality of Brain PET Images Using MR-Guided PET Reconstruction Technique With Integrated PET/MR.
Article in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Improving the Quality of Brain PET Images Using MR-Guided PET Reconstruction Technique With Integrated PET/MR.Human brain mapping · 2025Article
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7 authors.
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Abstract
To evaluate the performance of an MR-guided PET reconstruction method in enhancing the image quality of brain PET images acquired with an integrated PET/MR system. We implemented an MR-guided PET reconstruction (MRg) algorithm in an integrated PET/MR system and conducted both phantom and clinical studies. The PET images of a Hoffman phantom were reconstructed using the MRg algorithm and routine Ordered Subsets Expectation Maximization (OSEM) algorithm. Image quality metrics were calculated to investigate the dose effects, number of iterations, and penalization factor (β). In the clinical study, the PET images of 30 patients without brain lesions, two patients with diffuse large B cell lymphoma (DLBCL), 18 patients with Parkinson's disease (PD) and one patient with cavernous angioma were reconstructed using MRg and OSEM, respectively. Qualitative and quantitative assessments were performed. In the phantom study, MRg images demonstrated improved image quality metrics (higher contrast and lower variability) compared to conventional OSEM, particularly at lower doses. The penalization factor
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