ArticleBMC pediatrics2025
Prevalence of liver disorders in children and adolescents with type 1 diabetes mellitus.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren and adolescents with type 1 diabetes mellitus (T1DM) occasionally develop liver disorders. Glycogenic hepatopathy and non-alcoholic fatty liver disease are the most common conditions found in patients with poor glycemic control. The main purpose of the study was to determine the frequency of liver disorders in children and adolescents with T1DM and to investigate a correlation with chronic complications or associated autoimmune diseases. The second aim was to investigate if glycogenic hepatopathy and non-alcoholic fatty liver disease could be differentiated non-invasively with MRI among patients with T1DM.
methodsIn 154 patients with T1DM age 2-20 years, clinical exam, laboratory tests and abdominal ultrasound were performed. Liver MRI and biopsy were performed in selected patients.
resultsOver the study period, 154 patients with T1DM were investigated (77 females and 77 males, ages 2-20, mean 14.2 ± 3.2 years, T1DM duration 1-18 years, mean 7.7 ± 4.1 years, BMI 20.6 ± 3.7 kg/m
conclusionLiver disorders in patients with T1DM are not as rare as previously thought, and glycogenic hepatopathy is the most common. A combination of liver enzymes and a liver ultrasound exam is a good initial screening and follow-up method for the evaluation of liver disorders. MRI represents a good non-invasive tool for the distinction between glycogen and fat accumulation, and might postpone liver biopsy beyond initial workup.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.