Evidence map›Paper›PMID 40760709›Full record

ArticleThe journal of headache and pain2025

Volume of the hypothalamus and its subunits in patients with episodic migraine without aura during interictal periods.

Irene Giardina, Antonio Di Renzo, Davide Chiffi, Francesca Giovannini, Giada Giuliani, Gabriele Sebastianelli, Francesco Casillo, Chiara Abagnale, Marta Altieri, Vittorio Di Piero and 2 more

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Article in The journal of headache and pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Irene Giardina *Department of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, Rome, 00185, Italy. i.giardina@uniroma1.it.
Antonio Di Renzo *IRCCS- Fondazione Bietti, Rome, Italy. antoniomp777@hotmail.it.
Davide ChiffiDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, Rome, 00185, Italy.
Francesca GiovanniniDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, Rome, 00185, Italy.
Giada GiulianiDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, Rome, 00185, Italy.
Gabriele SebastianelliDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy.
Francesco CasilloDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy.
Chiara AbagnaleDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy.
Marta AltieriDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, Rome, 00185, Italy.
Vittorio Di PieroDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, Rome, 00185, Italy.
Gianluca CoppolaDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy.
Francesca CaramiaDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, Rome, 00185, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe hypothalamus is thought to play a crucial role in the recurrence of migraine attacks, exhibiting activity prior to the onset of a migraine attack. Nonetheless, our comprehension of the roles of its subunits, especially during the interictal phase, remains limited. This study investigated hypothalamic volumetric differences between individuals with episodic migraine and healthy controls, with scans conducted during the interictal phase, free from the effects of preventative medications.

methodsWe analyzed hypothalamic volumes in 30 patients with episodic migraine without aura (MO), scanned during interictal periods and not on preventative medication, and in 30 healthy controls (HCs) matched for age and sex. Volumetric segmentation was performed of both hypothalamic subunits (anterior-inferior, anterior-superior, posterior, tubular inferior, and tubular superior) and the entire hypothalamus using magnetic resonance imaging (MRI) with T1-weighted sequences. General linear models were employed to evaluate volumetric differences after controlling for age, sex, and total brain volume.

resultsThe volumes of hypothalamic subunits and overall hypothalamus volumes exhibited no statistically significant differences between HCs and MO patients (p > 0.05). No associations were found between the clinical characteristics of MO and the total hypothalamic volume or its subunits.

conclusionsThese findings suggest that the hypothalamus and its subregions do not exhibit detectable volumetric alterations during the interictal phase in patients with migraine without aura.

Indexed as

HypothalamusMigraine without AuraAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedOrgan SizeYoung AdultFreesurferHypothalamusInterictalMigraineMRISegmentation

Identifiers

PMID40760709
PMCPMC12323135

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.