Evidence map›Paper›PMID 40760746›Full record

ReviewCurrent Alzheimer research2025

Exploring the Interconnections of Genetic, Lifestyle, and Epigenetic Influences on Brain Aging: A Comprehensive Review.

Shima Mehrabadi, Sama Barati

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current Alzheimer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shima MehrabadiMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Sama BaratiStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by progressive cognitive decline and memory loss. The etiology of AD is complex and multifactorial, with contributions from genetic, lifestyle, and environmental factors. Recent advances in genetics, epigenetics, and animal models have shed light on the underlying mechanisms of brain aging and the development of AD, revealing potential targets for therapeutic intervention. In this comprehensive review, we examine the current understanding of the genetic, lifestyle, and epigenetic factors that shape the landscape of brain aging and AD. We discuss recent findings in the field of AD genetics, including the role of the APOE gene, and the potential of novel genome-wide association studies to identify new genetic risk factors. We also review the impact of lifestyle factors, such as diet, exercise, and social engagement, on brain aging and AD, and explore the role of epigenetic mechanisms, such as DNA methylation and histone modifications, in shaping AD risk.

Indexed as

AgingAlzheimer DiseaseBrainEpigenesis, GeneticLife StyleAnimalsHumansAlzheimer's diseaseAPOE.dementiaepigeneticsgeneticslifestyle factors

Identifiers

PMID40760746

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.