ReviewAnnals of the New York Academy of Sciences2025
Harnessing hibernation: Unlocking nature's secrets for advances in healthy aging, critical care, and space exploration.
Review in Annals of the New York Academy of Sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Using Organoids to Unlock the Potential of Human Torpor for Spaceflight.Current stem cell reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Aging poses one of the greatest biomedical challenges of our time, with rising rates of frailty, sarcopenia, and cognitive decline globally. Preserving muscle and brain health is central to maintaining independence and quality of life in aging populations. This commentary explores how hibernation research, rooted in comparative physiology, offers unprecedented opportunities for drug discovery and therapeutic innovation. Hibernating animals exhibit remarkable abilities to regulate metabolism, protect the brain and muscles from atrophy, and prevent cellular damage under extreme conditions. These adaptations could inform new strategies for muscle preservation during inactivity, neuroprotection, and targeted temperature management, as well as critical needs in aging, neurocritical care, and space medicine. The bidirectional relationship between muscle and brain health underscores the potential for hibernation-inspired therapies to address both sarcopenia and cognitive decline. Applying these insights to space medicine and critical care settings could lead to groundbreaking solutions for unmet medical needs. Just as GLP-1 agonists emerged from the study of Gila monster venom, focusing on nature's extreme survivors may reveal overlooked molecular targets for drug development. By harnessing these adaptations, we can advance biomimicry in medical research and inspire sustainable solutions for healthy aging, critical care, and space exploration-offering new hope for patients, clinicians, and policymakers.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.