Evidence map›Paper›PMID 40760810›Full record

ArticleBrain and behavior2025

Frontal Theta Event-Related Oscillations During a Continuous Performance Test: The Influence of Trauma Type and Fluid Intelligence Polygenic Score.

Stacey Saenz de Viteri, Ashwini Pandey, Chella Kamarajan, Gayathri Pandey, Weipeng Kuang, Sivan Kinreich, Grace Chan, Martin H Plawecki, Marc A Schuckit, Bernice Porjesz and 1 more

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Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Stacey Saenz de ViteriDepartment of Psychiatry, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.
Ashwini PandeyDepartment of Psychiatry, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.
Chella KamarajanDepartment of Psychiatry, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.
Gayathri PandeyDepartment of Psychiatry, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.ORCID https://orcid.org/0000-0003-0889-3117
Weipeng KuangDepartment of Psychiatry, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.
Sivan KinreichDepartment of Psychiatry, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.
Grace ChanDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Martin H PlaweckiDepartment of Psychiatry, Indiana University, Indianapolis, Indiana, USA.
Marc A SchuckitDepartment of Psychiatry, University of California San Diego Medical School, San Diego, California, USA.
Bernice PorjeszDepartment of Psychiatry, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.
Jacquelyn L MeyersDepartment of Psychiatry, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7M
Genetic relationships between PTSD and Alcohol Use Disorder: Integrating GWAS and Deeply Phenotyped Longitudinal data.R01AA030010 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI ANANDA B AMSTADTER, Jacquelyn Leigh Meyers · 2022 to 2026
$3.1M
NIAAA NIH HHS R01AA030010NIAAA NIH HHS U10AA008401
6 · The paper itself

Abstract

backgroundTrauma exposure during adolescence can lead to impaired executive function and altered neural development in related cognitive control networks. Studies have shown that adolescents with a family history of alcohol use disorders have a disproportionately high rate of trauma exposure, as well as impaired response inhibition, making them particularly vulnerable to cognitive impairment and poor mental health outcomes in adulthood. While studies have suggested that this may be due partly to genetic influences, no study to our knowledge has investigated the influences of trauma exposure and polygenic scores (PGS) for cognitive function on later cognitive function.

methodsThis study used data from trauma-exposed individuals in the Collaborative Study on the Genetics of Alcoholism prospective cohort (N = 912), comprising offspring from alcohol-dependent high-risk and comparison families, to investigate main and interaction effects of PGS for cognitive function (fluid intelligence score, UK Biobank study) and trauma exposure (nonsexual assaultive, nonassaultive, sexual assaultive) on performance measures and frontal theta event-related oscillations (EROs) during a continuous performance test (CPT).

resultsA significant interaction between fluid intelligence PGS and nonsexual assaultive trauma was observed for CPT ERO power (B = 0.094, p < 0.01), such that individuals with a lower PGS who experienced a nonsexual assaultive traumatic exposure had lower frontal theta ERO power during the cued no-go condition of the CPT.

conclusionThese findings suggest that a polygenic predisposition for higher fluid intelligence may be associated with differences in neural response inhibition depending on trauma type.

Indexed as

Frontal LobeIntelligencePsychological TraumaTheta RhythmAdolescentAdultAlcoholismCognitionEvoked PotentialsExecutive FunctionFemaleHumansMaleMiddle AgedMultifactorial InheritanceNeuropsychological Tests

Identifiers

PMID40760810
PMCPMC12321974

What Socratic holds

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.