ArticleBrain and behavior2025
Exploration of the Therapeutic Time Window for Thrombectomy in Rat Models of Middle Cerebral Artery Ischemia-Reperfusion.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Latest evidence on transfer efficiency and patient outcomes in mothership versus drip-and-ship models for acute stroke management: a systematic review and meta-analysis.Frontiers in neurology · 2026Pooled it
- Impact of time from symptom onset to recanalization in acute anterior circulation large vessel occlusive stroke with same tissue window: A patient-level pooled analysis of the three randomized controlled trials.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Observational
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8 authors.
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Abstract
objectiveTo investigate the therapeutic time window of middle cerebral artery occlusion (MCAO) reperfusion in rats and the potential mechanism of injury beyond the time window.
methodsMale Sprague Dawley (SD) rats were randomly divided into eight groups: a sham operation group, six ischemia-reperfusion groups (reperfusion initiated 1, 2, 3, 4, 5, and 6 h after infarction, respectively), and a 24-h infarction group without reperfusion therapy. Neurological function scores were assessed 24 h after reperfusion, and then brain samples were collected to explore the mechanisms.
resultsAfter 4 h of MCAO reperfusion for 24 h, the infarct area reached its peak, while the neurological function score reached its bottom, and both indicators exhibited a trend toward stabilization. Additionally, a significant increase in the mortality rate was observed in the 5-h group. Compared to the MCAO 2-h group, the 5-h group exhibited a significant increase in the number of dead neurons, more serious disruption of the blood-brain barrier (BBB), and elevated expression levels of IL-6, IL1-β, and TNF-α.
conclusionTaken together, our study indicates that MCAO 4 h is likely to be the therapeutic time window for thrombectomy in rat models of middle cerebral artery ischemia-reperfusion. Reperfusion injury beyond the time window leads to more severe disruption of the BBB, a significant increase in inflammatory products, and may ultimately result in a significant decline in neural function scores.
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