Evidence map›Paper›PMID 40760936›Full record

ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2025

Bilateral Enlarged Vestibular Aqueduct: Auditory, Genetic and Radiological Characterization, and Benefits of Cochlear Implants.

Augustin Vigouroux, Benjamin Glemain, Renato Torres, Laurence Jonard, Natalie Loundon, Evelyne Ferrary, Isabelle Mosnier, Hannah Daoudi, Sandrine Marlin, Ghizlene Lahlou

Abstract read
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In one paragraph

Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Augustin VigourouxAPHP, Sorbonne Université, GHU Pitié-Salpêtrière, Service d'ORL et de chirurgie cervico-faciale, UF Implants Auditifs, Paris, France.
Benjamin GlemainSorbonne Université, Inserm, Institut Pierre-Louis d'Épidémiologie et de Santé Publique, Paris, France.
Renato TorresUniversité Paris Cité, Institut Pasteur, AP-HP, Inserm, Fondation Pour l'Audition, Institut de l'Audition, IHU reConnect, Technology and Gene Therapy for Deafness, Paris, France.
Laurence JonardAPHP Université Paris Cité, Hôpital Necker-Enfants Malades, Centre de références «Surdités Génétiques», Fédération de Génétique, Centre de Recherche en Audiologie (CREA), Paris, France.
Natalie LoundonAPHP, Université Paris Cité, Hôpital Necker Enfants Malades, Service d'ORL et de chirurgie cervico-faciale, Paris, France.
Evelyne FerraryUniversité Paris Cité, Institut Pasteur, AP-HP, Inserm, Fondation Pour l'Audition, Institut de l'Audition, IHU reConnect, Technology and Gene Therapy for Deafness, Paris, France.
Isabelle MosnierAPHP, Sorbonne Université, GHU Pitié-Salpêtrière, Service d'ORL et de chirurgie cervico-faciale, UF Implants Auditifs, Paris, France.
Hannah DaoudiAPHP, Sorbonne Université, GHU Pitié-Salpêtrière, Service d'ORL et de chirurgie cervico-faciale, UF Implants Auditifs, Paris, France.
Sandrine MarlinAPHP Université Paris Cité, Hôpital Necker-Enfants Malades, Centre de références «Surdités Génétiques», Fédération de Génétique, Centre de Recherche en Audiologie (CREA), Paris, France.
Ghizlene LahlouAPHP, Sorbonne Université, GHU Pitié-Salpêtrière, Service d'ORL et de chirurgie cervico-faciale, UF Implants Auditifs, Paris, France.ORCID https://orcid.org/0000-0002-1067-045X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe study aimed to describe the auditory phenotype of patients with bilateral enlarged vestibular aqueduct, including benefits of cochlear implantation, and to look for genotype-phenotype correlation. STUDY

designRetrospective single-center study.

settingTertiary adult reference center.

methodsFifty-eight patients were included. Evolution of pure tone and speech audiometry was analyzed. Cochlear size, vestibular aqueduct width, and endolymphatic duct and sac volume were assessed on both computed tomography scan and magnetic resonance imaging. Genetic explorations were documented, and genotype-phenotype correlations were explored. Outcomes after cochlear implant (CI) were analyzed.

resultsHearing loss was diagnosed at 4 ± 4.0 years, being initially severe-to-profound in 74% of the ears. Sudden sensorineural hearing loss concerned 54% of patients. Both vestibular aqueduct and endolymphatic sac showed symmetric measurements (P < .001). Patients with SLC26A4 biallelic alterations (n = 22) had more associated thyroid disorders (14/22 vs 3/31, P < .001), earlier (2 ± 1.6 years old [yo] vs 5 ± 4.5 yo, P < .001) and lower age-adjusted pure-tone average (P < .001, two-way analysis of variance), and greater endolymphatic sac volume (369 ± 118.1 mm

conclusionThe auditory phenotype of patients with bilateral enlarged vestibular aqueduct is variable but seems to be more severe in case of biallelic alterations of SLC26A4. However, cochlear implantation benefits to these patients, regardless of genotype.

Indexed as

Cochlear ImplantationCochlear ImplantsHearing Loss, SensorineuralVestibular AqueductAdolescentAdultAudiometry, Pure-ToneChildChild, PreschoolFemaleGenetic Association StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedPhenotypeSLC26A4 protein, humanSulfate Transporterscochlear implantenlarged vestibular aqueductgeneticshearing loss

Identifiers

PMID40760936
PMCPMC12574651

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.