IKZF3 promotes gastric cancer progression via Hedgehog signaling activation and is targetable by SANT-1.

Muhammad Ali, Shantanu Baral, Jun Ren, Liuhua Wang, Bin Liu, Sen Wang, Daorong Wang

Abstract read

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Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Muhammad AliDepartment of General Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China.

Shantanu BaralDepartment of General Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China.

Jun RenDepartment of General Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China.

Liuhua WangDepartment of General Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China.

Bin LiuDepartment of General Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China.

Sen WangGastric Cancer Centre, Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Daorong WangDepartment of General Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elevated expression of Aiolos family zinc finger 3 (IKZF3), a transcription factor crucial for lymphocyte maturation, is observed in hematological cancers. However, its role in gastric cancer (GC) remains unclear. We detect the increased IKZF3 levels in GC tissues using immunohistochemical, qRT-PCR and western blot analysis. The function of IKZF3 in GC cells is further studied through CCK-8, Transwell, colony formation, scratch wound healing, and flow cytometry assays.

Indexed as

Hedgehog ProteinsIkaros Transcription FactorSignal TransductionStomach NeoplasmsAnimalsCell Line, TumorCell MovementCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMaleMiceMice, Inbred BALB CMice, NudeHedgehog ProteinsIkaros Transcription FactorIKZF3 protein, humanSmoothened ReceptorSMO protein, humangastric cancerIKZF3SANT-1SMOtranscription factor

Identifiers

PMID40761106

DOI10.3724/abbs.2025103

PMCPMC12900698

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.