ReviewCurrent drug research reviews2025
Radiosensitizing Effects of Metformin on Ionizing Irradiation: An Overview of Animal and Clinical Studies.
Review in Current drug research reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundRadiation therapy is the most common modality to treat various types of cancers. The use of radiosensitizers as an adjuvant therapy to increase the sensitivity of tumors against radiation and to improve the efficiency of radiotherapy has risen over the past years. Metformin, the first-line drug in type two diabetes has attracted the researcher's attention because of its anti-cancer and anti-proliferative properties and many studies have been conducted to investigate the radiosensitization effects of metformin in different types of malignancies.
objectiveThis review aims to gather the existing evidence of radiosensitizing effects of metformin in animal and clinical studies.
methodsVarious databases like PubMed, Scopus, and Google Scholar were searched over a period of 35 years for this review.
resultsThe results include 54 studies on the radiosensitization effect of metformin in
conclusionThis review shows that metformin in animal and clinical studies appears to be a potential radiosensitizer for many types of cancers. However, further investigations are needed to determine whether metformin can be used as a radiosensitizer in adjuvant radiotherapy.
Indexed as
Identifiers
40761109What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.