ReviewJournal of oral microbiology2025
Altered oral microbiome composition in mental disorders: a systematic review and meta-analysis.
Review in Journal of oral microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Physical Activity, Dietary Inflammatory Potential, and Depressive Symptoms Among U.S. Adults: The Potential Contribution of Oral Microbial Dysbiosis.Healthcare (Basel, Switzerland) · 2026Article
- The Oral and Nasal Gateway Microbiomes: Salivaomics and Systemic Health at the Airway-Digestive Interface.Microorganisms · 2026Review
- Pilot Study of Oral Microbiome and Psychoneurological Symptom Cluster in Breast Cancer.Nursing research · 2026Article
- Olanzapine-related oral health impairments: a scoping review and construction of a management framework.BMC oral health · 2026Article
- Targeting Gut Microbiota by DPP-4 Inhibitors in Obesity: Mechanistic Insights and Therapeutic Implications.Current nutrition reports · 2026Review
- The Oral Microbiome and Systemic Health: Current Insights into the Mouth-Body Connection.Life (Basel, Switzerland) · 2026Review
- Article
- Dietary diversity and life satisfaction as mediators in the relationship between oral health and depression among older adults in china: a cross-sectional study.Frontiers in psychology · 2025Article
- Parents-child multiple sites of microbial and metabolic signatures in autism spectrum disorder.Frontiers in microbiology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Emerging research underscores the gut-brain axis in mental disorder pathophysiology, yet the oral microbiome's contribution to mental health remains underexplored. Elucidating oral microbial signatures in mental and neurological disorders may reveal novel pathobiological mechanisms and advance biomarker discovery for precision diagnostics and microbiota-targeted interventions. Methods: This systematic review and meta-analysis investigates oral microbiota alterations across 6 different mental disorders, by synthesizing data from 20 case-control studies retrieved from PubMed, Embase, and Cochrane Library. Relative microbial abundance and beta diversity indices were extracted from between-group comparisons. Random-effects meta-analyses were conducted for alpha diversity to characterize microbiota differences between patients and controls. Results: Key findings included a significantly higher Simpson Index in patients (SMD = 0.42; 95% CI, 0.25 to 0.60) compared to controls. Beta diversity varied significantly only in SZ and MDD. Condition-specific variations in microbial abundance were observed: Conclusion: Collectively, the meta-analytical synthesis suggests alterations in oral microbiota diversity across mental disorders. Disease-associated microbial shifts highlight the oral microbiome as a candidate factor warranting further investigation for potential diagnostic applications and microbial-targeted therapeutic strategies.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.