Evidence map›Paper›PMID 40761480›Full record

ArticleMedComm2025

The Biological Characteristics and Mouse Model of Lassa Virus From the First Imported Case in China.

Yanan Zhou, Junbin Wang, Ranran Cao, Yun Yang, Yuliang Feng, Cong Tang, Hao Yang, Qing Huang, Wenhai Yu, Haixuan Wang and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Yanan ZhouNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
Junbin WangNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
Ranran CaoSichuan Center for Disease Control and Prevention Chengdu China.
Yun YangNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
Yuliang FengSichuan Center for Disease Control and Prevention Chengdu China.
Cong TangNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
Hao YangNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
Qing HuangNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
Wenhai YuNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
Haixuan WangNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
Jiandong ShiNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.ORCID https://orcid.org/0000-0002-3329-1014
Kaiyun DingNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
Longhai YuanNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
Qing DaiNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
Xingping ZhaoNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
Haiyan LiNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
Mengli YangNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
Fangyu LuoNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
Fanli ZhuNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
Yong ZhangNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
Daoju WuNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
Xiaorong YangSichuan Center for Disease Control and Prevention Chengdu China.
Shuaiyao LuNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.ORCID https://orcid.org/0000-0003-1675-9735
Qiangming SunNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.ORCID https://orcid.org/0000-0003-1376-3827
Li ZhangSichuan Center for Disease Control and Prevention Chengdu China.
Youchun WangNational Kunming High-Level Biosafety Primate Research Center，State Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lassa fever (LF) is a fatal hemorrhagic disease caused by the Lassa virus (LASV), which mainly spreads in Africa. As China's interactions with Africa become more frequent, the risk of LF being imported into China also rises, making the study of LASV increasingly urgent. In this study, the Lineage IV LASV strain was successfully isolated from the first imported case in China. Compared with the LASV genome, the isolated strain may exhibit greater infectivity and interspecies transmission capabilities. We successfully established BALB/c, C57BL/6, and AG129 mouse infection models and found that intranasal inoculation was the most stable infection method. Select the anti-LASV drug LHF-535 for preliminary evaluation, further confirming the stability of the model. In summary, the isolated strain exhibits enhanced transmission capabilities and may spread between mice via the respiratory tract, meriting greater attention and emphasis. This study will bridge the gap in China's independent P4-level pathogen isolation, meet national biosafety and strategic needs, and provide certain support for LASV research.

Indexed as

biological characteristicsLassa virusmouse infection modelvirus isolation

Identifiers

PMID40761480
PMCPMC12318830

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.