Evidence map›Paper›PMID 40761513›Full record

ArticleMaterials today. Bio2025

High-mobility network hydrogel microsphere system to combat chondrocyte senescence for enhanced cartilage repair and regeneration.

Fangqi Xu, Chen Zhuang, Lufeng Yao, Yiwen Xu, Qihua Cao, Zherui Fu, Longfeng Wang, Yuan Zhu, Deting Xue, Ning Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fangqi XuDepartment of Orthopedics Surgery, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, 310000, PR China.
Chen ZhuangAlberta Institute, Wenzhou Medical University, Wenzhou, 315000, PR China.
Lufeng YaoDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, 310000, PR China.
Yiwen XuDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, 310000, PR China.
Qihua CaoDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, 310000, PR China.
Zherui FuDepartment of Orthopedics Surgery, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, 310000, PR China.
Longfeng WangDepartment of Orthopedics Surgery, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, 310000, PR China.
Yuan ZhuDepartment of Orthopedics Surgery, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, 310000, PR China.
Deting XueDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, 310000, PR China.
Ning ZhangDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, 310000, PR China.
Xiaohua YuDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, 310000, PR China.
Gangfeng HuDepartment of Orthopedics Surgery, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, 310000, PR China.
Feng LinDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, 310000, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular senescence plays a crucial role in the progression of various diseases, and targeting senescence is a potential therapeutic strategy for osteoarthritis (OA). However, the complex biomechanical environment surrounding chondrocytes significantly affects their senescence process. Currently, few biomaterials are available that have the ability to modulate stresses and counteract chondrocyte senescence. In this study, we used cationic liposomes as the core of the crosslinked structure of the hydrogel network through imine bonding to construct a high-mobility network hydrogel microsphere system (Res@Lipo@HMs). The deformability of liposomes endowed mobility to the crosslinked structure of the hydrogel network. This system not only enhanced joint lubrication through a rolling mechanism but also distributed mechanical stress on chondrocytes by increasing the elastic deformation capacity of the microspheres. Moreover, this approach delayed chondrocyte senescence, improved chondrocyte physiological function, and slowed down OA progression by enhancing mitochondrial function and inhibiting senescence pathways. This study offers new insights into antisenescence strategies for chondrocyte therapy.

Indexed as

Chondrocyte senescenceHydrogel microspheresMechanical stress modulationOsteoarthritis therapy

Identifiers

PMID40761513
PMCPMC12320708

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.