ArticleJournal of multidisciplinary healthcare2025
Electro-Acupuncture for Diminished Ovarian Reserve: Protocol for a Randomized, Placebo-Controlled Trial.
Article in Journal of multidisciplinary healthcare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Acupuncture for premature ovarian insufficiency: a systemic neuroendocrine perspective.Frontiers in endocrinology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Diminished ovarian reserve (DOR) is characterized by a reduced response to ovarian stimulation and a decline in fertility potential among women of reproductive age. Although previous research has suggested potential benefits of acupuncture for DOR, the evidence remains inconclusive. This study evaluates the effectiveness of electro-acupuncture in patients with DOR by examining changes in ovarian reserve indicators and reproductive outcomes. The study aims to determine whether electro-acupuncture significantly improves ovarian reserve markers and reproductive outcomes in women with DOR, thereby informing clinical decision-making. Methods and Analysis: A randomized, subject- and assessor-blinded, placebo-controlled trial will be conducted in two hospitals in Shenzhen, China. A total of 112 participants (20-48 yr) will be allocated to either the electro-acupuncture (EA) group or the sham electro-acupuncture (SA) group in a 1:1 ratio. Each participant will receive 3 treatment sessions per week over a continuous period of 12 weeks. The primary outcome is the change in antral follicle count, with an anticipated mean increase of approximately 2.2 follicles based on previous meta-analytic findings. Secondary outcomes will include changes in serum basal hormone levels, serum anti-Müllerian hormone levels, and self-rating anxiety, depression, and Kupperman Index scores compared to baseline. Subgroup analyses will explore variations in pregnancy outcomes (eg, clinical pregnancy rate, live birth rate), age groups (≤32, 32-40, ≥40 years), and ovulation induction outcomes (eg, number of oocytes retrieved, MII oocyte rate). Adverse events will be recorded following each session of treatment, and a blinded evaluation is conducted upon the completion of the treatment. Study results will be primarily analyzed using the full analysis set, supplemented by the per-protocol set. Ethics and Dissemination: This protocol have been approved by the Ethics Committee of Shenzhen Hospital of Shanghai University of Traditional Chinese Medicine (No.2023-LHQZYYYXLL-KY-147) and Luohu People's Hospital (No.2024-LHQRMYY-KYLL-009). The results will be disseminated to participants, the public, and other relevant groups through open-access journals and conferences. Trial Registration Number: ISRCTN:69623204. Registered on 10 January 2024.
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